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Target Report Card

Target Name and Classification

Target ID CHEMBL5874
Preferred Name Solute carrier family 2, facilitated glucose transporter member 4
Synonyms GLUT-4 | GLUT4 | Glucose transporter type 4, insulin-responsive | SLC2A4 | Solute carrier family 2, facilitated glucose transporter member 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc02 family of hexose and sugar alcohol transporters

Target Components

Component Description Relationship Accession
Solute carrier family 2, facilitated glucose transporter member 4 SINGLE PROTEIN P14672

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000181856
Ensembl ENSG00000181856
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005768 (endosome)
GO:0005771 (multivesicular body)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005905 (clathrin-coated pit)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0012505 (endomembrane system)
GO:0012506 (vesicle membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030136 (clathrin-coated vesicle)
GO:0030140 (trans-Golgi network transport vesicle)
GO:0030315 (T-tubule)
GO:0030659 (cytoplasmic vesicle membrane)
GO:0031982 (vesicle)
GO:0032593 (insulin-responsive compartment)
GO:0042383 (sarcolemma)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005215 (transporter activity)
GO:0005355 (glucose transmembrane transporter activity)
GO:0005515 (protein binding)
GO:0022857 (transmembrane transporter activity)
GO:0022891 (substrate-specific transmembrane transporter activity)
GO:0055056 (D-glucose transmembrane transporter activity)
GO Biological Process GO:0005975 (carbohydrate metabolic process)
GO:0006810 (transport)
GO:0008643 (carbohydrate transport)
GO:0010021 (amylopectin biosynthetic process)
GO:0015758 (glucose transport)
GO:0032869 (cellular response to insulin stimulus)
GO:0042593 (glucose homeostasis)
GO:0045471 (response to ethanol)
GO:0046323 (glucose import)
GO:0050873 (brown fat cell differentiation)
GO:0055085 (transmembrane transport)
GO:0071456 (cellular response to hypoxia)
GO:0071470 (cellular response to osmotic stress)
GO:1904659 (glucose transmembrane transport)
Wikipedia GLUT4

Target Cross References - Protein

canSAR P14672
Human Protein Atlas ENSG00000181856
IntAct P14672
Open Targets ENSG00000181856
PharmGKB PA35879
Reactome R-HSA-1445148 (Translocation of GLUT4 to the plasma membrane.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-428790 (Facilitative Na+-independent glucose transporters.)
R-HSA-70153 (Glucose transport.)
UniProt P14672 Q05BQ3 Q14CX2

Target Cross References - Domain

InterPro IPR002441 (Glc_transpt_4.)
IPR003663 (Sugar/inositol_transpt.)
IPR005828 (MFS_sugar_transport-like.)
IPR005829 (Sugar_transporter_CS.)
IPR020846 (MFS_dom.)
Pfam PF00083 (Sugar_tr)