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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5870
Target Type SINGLE PROTEIN
Preferred Name Centromere-associated protein E
Synonyms CENP-E | CENPE | Centromere protein E | Centromere-associated protein E | Kinesin-7 | Kinesin-related protein CENPE
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Centromere-associated protein E SINGLE PROTEIN Q02224

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138778
Ensembl ENSG00000138778
GO Cellular Component GO:0000775 (chromosome, centromeric region)
GO:0000776 (kinetochore)
GO:0000777 (condensed chromosome kinetochore)
GO:0000779 (condensed chromosome, centromeric region)
GO:0000940 (condensed chromosome outer kinetochore)
GO:0005634 (nucleus)
GO:0005694 (chromosome)
GO:0005737 (cytoplasm)
GO:0005819 (spindle)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005871 (kinesin complex)
GO:0005874 (microtubule)
GO:0015630 (microtubule cytoskeleton)
GO:0016020 (membrane)
GO:0030496 (midbody)
GO:1990023 (mitotic spindle midzone)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0003777 (microtubule motor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008017 (microtubule binding)
GO:0016887 (ATPase activity)
GO:0043515 (kinetochore binding)
GO Biological Process GO:0000278 (mitotic cell cycle)
GO:0006890 (retrograde vesicle-mediated transport, Golgi to ER)
GO:0007018 (microtubule-based movement)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007062 (sister chromatid cohesion)
GO:0007067 (mitotic nuclear division)
GO:0007079 (mitotic chromosome movement towards spindle pole)
GO:0007080 (mitotic metaphase plate congression)
GO:0007275 (multicellular organism development)
GO:0019886 (antigen processing and presentation of exogenous peptide antigen via MHC class II)
GO:0030071 (regulation of mitotic metaphase/anaphase transition)
GO:0045860 (positive regulation of protein kinase activity)
GO:0051301 (cell division)
GO:0051315 (attachment of mitotic spindle microtubules to kinetochore)
GO:0051382 (kinetochore assembly)
Wikipedia Centromere_protein_E

Target Cross References - Protein

canSAR Q02224
Human Protein Atlas ENSG00000138778
IntAct Q02224
Open Targets ENSG00000138778
PharmGKB PA26400
Reactome R-HSA-2132295 (MHC class II antigen presentation.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-6811434 (COPI-dependent Golgi-to-ER retrograde traffic.)
R-HSA-68877 (Mitotic Prometaphase.)
R-HSA-983189 (Kinesins.)
UniProt A6NKY9 A8K2U7 Q02224 Q4LE75

Target Cross References - Domain

InterPro IPR001752 (Kinesin_motor_dom.)
IPR019821 (Kinesin_motor_CS.)
IPR027417 (P-loop_NTPase.)
IPR033066 (CENP-E.)
Pfam PF00225 (Kinesin)

Target Cross References - Structure

PDBe 1T5C 5JVP
CREDO 1T5C 5JVP
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