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Target Report Card

Target Name and Classification

Target ID CHEMBL5866
Target Type SINGLE PROTEIN
Preferred Name Catenin beta-1
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Catenin beta-1 SINGLE PROTEIN P35222

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038464 Axin1/beta-catenin PROTEIN COMPLEX
CHEMBL3038511 TCF4/beta-catenin PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168036
Ensembl ENSG00000168036
GO Cellular Component GO:0005938 (cell cortex)
GO:0030027 (lamellipodium)
GO:0000922 (spindle pole)
GO:0005654 (nucleoplasm)
GO:0005912 (adherens junction)
GO:0005813 (centrosome)
GO:0005829 (cytosol)
GO:0005923 (bicellular tight junction)
GO:0016342 (catenin complex)
GO:0030018 (Z disc)
GO:0032993 (protein-DNA complex)
GO:0045177 (apical part of cell)
GO:0005913 (cell-cell adherens junction)
GO:0005925 (focal adhesion)
GO:0016020 (membrane)
GO:0016600 (flotillin complex)
GO:0070062 (extracellular exosome)
GO:0005634 (nucleus)
GO:0005667 (transcription factor complex)
GO:0005719 (nuclear euchromatin)
GO:0005916 (fascia adherens)
GO:0034750 (Scrib-APC-beta-catenin complex)
GO:0044798 (nuclear transcription factor complex)
GO:0048471 (perinuclear region of cytoplasm)
GO:0043234 (protein complex)
GO:0005737 (cytoplasm)
GO:0016323 (basolateral plasma membrane)
GO:0030877 (beta-catenin destruction complex)
GO:0071944 (cell periphery)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0016328 (lateral plasma membrane)
GO:0030054 (cell junction)
GO:0031528 (microvillus membrane)
GO:0070369 (beta-catenin-TCF7L2 complex)
GO Molecular Function GO:0045296 (cadherin binding)
GO:0019900 (kinase binding)
GO:0019903 (protein phosphatase binding)
GO:1990188 (euchromatin binding)
GO:0030331 (estrogen receptor binding)
GO:0003690 (double-stranded DNA binding)
GO:0019899 (enzyme binding)
GO:0044325 (ion channel binding)
GO:0045294 (alpha-catenin binding)
GO:0035257 (nuclear hormone receptor binding)
GO:0070411 (I-SMAD binding)
GO:0003713 (transcription coactivator activity)
GO:0004871 (signal transducer activity)
GO:0044212 (transcription regulatory region DNA binding)
GO:0046332 (SMAD binding)
GO:0050681 (androgen receptor binding)
GO:0070412 (R-SMAD binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO Biological Process GO:0001569 (patterning of blood vessels)
GO:0001702 (gastrulation with mouth forming second)
GO:0003266 (regulation of secondary heart field cardioblast proliferation)
GO:0006351 (transcription, DNA-templated)
GO:0033234 (negative regulation of protein sumoylation)
GO:0034394 (protein localization to cell surface)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0042692 (muscle cell differentiation)
GO:0045743 (positive regulation of fibroblast growth factor receptor signaling pathway)
GO:0045976 (negative regulation of mitotic cell cycle, embryonic)
GO:0050808 (synapse organization)
GO:0060441 (epithelial tube branching involved in lung morphogenesis)
GO:0060769 (positive regulation of epithelial cell proliferation involved in prostate gland development)
GO:0061154 (endothelial tube morphogenesis)
GO:0071363 (cellular response to growth factor stimulus)
GO:2000008 (regulation of protein localization to cell surface)
GO:2000017 (positive regulation of determination of dorsal identity)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0009948 (anterior/posterior axis specification)
GO:0035112 (genitalia morphogenesis)
GO:0042493 (response to drug)
GO:0044334 (canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)
GO:0045765 (regulation of angiogenesis)
GO:0048660 (regulation of smooth muscle cell proliferation)
GO:0051571 (positive regulation of histone H3-K4 methylation)
GO:0060066 (oviduct development)
GO:0060440 (trachea formation)
GO:0060479 (lung cell differentiation)
GO:0060742 (epithelial cell differentiation involved in prostate gland development)
GO:0070602 (regulation of centromeric sister chromatid cohesion)
GO:0009954 (proximal/distal pattern formation)
GO:0022009 (central nervous system vasculogenesis)
GO:0030316 (osteoclast differentiation)
GO:0030521 (androgen receptor signaling pathway)
GO:0031016 (pancreas development)
GO:0031641 (regulation of myelination)
GO:0035115 (embryonic forelimb morphogenesis)
GO:0045603 (positive regulation of endothelial cell differentiation)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0048096 (chromatin-mediated maintenance of transcription)
GO:0048538 (thymus development)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0072054 (renal outer medulla development)
GO:0000578 (embryonic axis specification)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001764 (neuron migration)
GO:0001840 (neural plate development)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002089 (lens morphogenesis in camera-type eye)
GO:0006921 (cellular component disassembly involved in execution phase of apoptosis)
GO:0007160 (cell-matrix adhesion)
GO:0007268 (synaptic transmission)
GO:0016337 (single organismal cell-cell adhesion)
GO:0019827 (stem cell population maintenance)
GO:0030997 (regulation of centriole-centriole cohesion)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0034333 (adherens junction assembly)
GO:0042733 (embryonic digit morphogenesis)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0048145 (regulation of fibroblast proliferation)
GO:0048599 (oocyte development)
GO:0048617 (embryonic foregut morphogenesis)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0072079 (nephron tubule formation)
GO:0090279 (regulation of calcium ion import)
GO:1901215 (negative regulation of neuron death)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006915 (apoptotic process)
GO:0008285 (negative regulation of cell proliferation)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0021819 (layer formation in cerebral cortex)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032355 (response to estradiol)
GO:0035050 (embryonic heart tube development)
GO:0035315 (hair cell differentiation)
GO:0043410 (positive regulation of MAPK cascade)
GO:0044336 (canonical Wnt signaling pathway involved in negative regulation of apoptotic process)
GO:0045087 (innate immune response)
GO:0048715 (negative regulation of oligodendrocyte differentiation)
GO:0051973 (positive regulation of telomerase activity)
GO:0060484 (lung-associated mesenchyme development)
GO:0060492 (lung induction)
GO:0060789 (hair follicle placode formation)
GO:0060916 (mesenchymal cell proliferation involved in lung development)
GO:0061549 (sympathetic ganglion development)
GO:0090263 (positive regulation of canonical Wnt signaling pathway)
GO:2000144 (positive regulation of DNA-templated transcription, initiation)
GO:0001708 (cell fate specification)
GO:0001837 (epithelial to mesenchymal transition)
GO:0032481 (positive regulation of type I interferon production)
GO:0036023 (embryonic skeletal limb joint morphogenesis)
GO:0042659 (regulation of cell fate specification)
GO:0043065 (positive regulation of apoptotic process)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0048489 (synaptic vesicle transport)
GO:0072053 (renal inner medulla development)
GO:2001234 (negative regulation of apoptotic signaling pathway)
GO:0001701 (in utero embryonic development)
GO:0001711 (endodermal cell fate commitment)
GO:0003337 (mesenchymal to epithelial transition involved in metanephros morphogenesis)
GO:0007155 (cell adhesion)
GO:0010909 (positive regulation of heparan sulfate proteoglycan biosynthetic process)
GO:0012501 (programmed cell death)
GO:0016055 (Wnt signaling pathway)
GO:0031069 (hair follicle morphogenesis)
GO:0042129 (regulation of T cell proliferation)
GO:0045453 (bone resorption)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0048469 (cell maturation)
GO:0051145 (smooth muscle cell differentiation)
GO:0071681 (cellular response to indole-3-methanol)
GO:0072033 (renal vesicle formation)
GO:0072182 (regulation of nephron tubule epithelial cell differentiation)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007398 (ectoderm development)
GO:0007403 (glial cell fate determination)
GO:0009950 (dorsal/ventral axis specification)
GO:0030539 (male genitalia development)
GO:0033077 (T cell differentiation in thymus)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0060070 (canonical Wnt signaling pathway)
GO:0061198 (fungiform papilla formation)
GO:0061324 (canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)
Wikipedia Beta-catenin

Target Cross References - Protein

canSAR P35222
CGD Mental retardation, autosomal dominant, 19
Human Protein Atlas ENSG00000168036
IntAct P35222
PharmGKB PA27013
TIMBAL Beta-catenin
UniProt Q8NI94 Q9H391 P35222 A8K1L7 Q8NEW9

Target Cross References - Domain

InterPro IPR000225 (Armadillo.)
IPR011989 (ARM-like.)
IPR013284 (Beta-catenin.)
IPR016024 (ARM-type_fold.)
Pfam PF00514 (Arm)

Target Cross References - Structure

PDBe 3TX7 1JDH 1P22 4DJS 1G3J 2Z6H 3FQR 1QZ7 2GL7 3SL9 1JPW 1LUJ 1T08 3DIW 1TH1 3FQN 3SLA
CREDO 3TX7 1JDH 1P22 4DJS 1G3J 2Z6H 3FQR 1QZ7 2GL7 3SL9 1JPW 1LUJ 1T08 3DIW 1TH1 3FQN 3SLA
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