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Target Report Card

Target Name and Classification

Target ID CHEMBL5866
Preferred Name Catenin beta-1
Synonyms Beta-catenin | CTNNB | CTNNB1 | Catenin beta-1 | PRO2286
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Catenin beta-1 SINGLE PROTEIN P35222

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3038511 TCF4/beta-catenin PROTEIN COMPLEX
CHEMBL3038464 Axin1/beta-catenin PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000168036
Ensembl ENSG00000168036
GO Cellular Component GO:0000922 (spindle pole)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005719 (nuclear euchromatin)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0005815 (microtubule organizing center)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0005912 (adherens junction)
GO:0005913 (cell-cell adherens junction)
GO:0005916 (fascia adherens)
GO:0005923 (bicellular tight junction)
GO:0005925 (focal adhesion)
GO:0005938 (cell cortex)
GO:0014704 (intercalated disc)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016328 (lateral plasma membrane)
GO:0016342 (catenin complex)
GO:0016600 (flotillin complex)
GO:0030018 (Z disc)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO:0030877 (beta-catenin destruction complex)
GO:0031253 (cell projection membrane)
GO:0031528 (microvillus membrane)
GO:0032993 (protein-DNA complex)
GO:0034750 (Scrib-APC-beta-catenin complex)
GO:0043005 (neuron projection)
GO:0043198 (dendritic shaft)
GO:0043234 (protein complex)
GO:0043296 (apical junction complex)
GO:0044798 (nuclear transcription factor complex)
GO:0045177 (apical part of cell)
GO:0045202 (synapse)
GO:0048471 (perinuclear region of cytoplasm)
GO:0070062 (extracellular exosome)
GO:0070369 (beta-catenin-TCF7L2 complex)
GO:0071664 (catenin-TCF7L2 complex)
GO:0071944 (cell periphery)
GO:1990907 (beta-catenin-TCF complex)
GO:1990909 (Wnt signalosome)
GO Molecular Function GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0003677 (DNA binding)
GO:0003682 (chromatin binding)
GO:0003690 (double-stranded DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003713 (transcription coactivator activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0008134 (transcription factor binding)
GO:0019899 (enzyme binding)
GO:0019900 (kinase binding)
GO:0019901 (protein kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0030331 (estrogen receptor binding)
GO:0032403 (protein complex binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0035257 (nuclear hormone receptor binding)
GO:0044212 (transcription regulatory region DNA binding)
GO:0044325 (ion channel binding)
GO:0045294 (alpha-catenin binding)
GO:0045296 (cadherin binding)
GO:0046332 (SMAD binding)
GO:0050681 (androgen receptor binding)
GO:0050998 (nitric-oxide synthase binding)
GO:0070411 (I-SMAD binding)
GO:0070491 (repressing transcription factor binding)
GO:0098641 (cadherin binding involved in cell-cell adhesion)
GO:1990188 (euchromatin binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000578 (embryonic axis specification)
GO:0000904 (cell morphogenesis involved in differentiation)
GO:0001501 (skeletal system development)
GO:0001569 (patterning of blood vessels)
GO:0001570 (vasculogenesis)
GO:0001658 (branching involved in ureteric bud morphogenesis)
GO:0001701 (in utero embryonic development)
GO:0001702 (gastrulation with mouth forming second)
GO:0001706 (endoderm formation)
GO:0001708 (cell fate specification)
GO:0001709 (cell fate determination)
GO:0001711 (endodermal cell fate commitment)
GO:0001764 (neuron migration)
GO:0001822 (kidney development)
GO:0001837 (epithelial to mesenchymal transition)
GO:0001840 (neural plate development)
GO:0001889 (liver development)
GO:0001944 (vasculature development)
GO:0002052 (positive regulation of neuroblast proliferation)
GO:0002053 (positive regulation of mesenchymal cell proliferation)
GO:0002089 (lens morphogenesis in camera-type eye)
GO:0003266 (regulation of secondary heart field cardioblast proliferation)
GO:0003338 (metanephros morphogenesis)
GO:0003340 (negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007398 (ectoderm development)
GO:0007399 (nervous system development)
GO:0007403 (glial cell fate determination)
GO:0007494 (midgut development)
GO:0007507 (heart development)
GO:0008283 (cell proliferation)
GO:0008284 (positive regulation of cell proliferation)
GO:0008285 (negative regulation of cell proliferation)
GO:0009725 (response to hormone)
GO:0009948 (anterior/posterior axis specification)
GO:0009950 (dorsal/ventral axis specification)
GO:0009953 (dorsal/ventral pattern formation)
GO:0009954 (proximal/distal pattern formation)
GO:0009987 (cellular process)
GO:0010468 (regulation of gene expression)
GO:0010628 (positive regulation of gene expression)
GO:0010629 (negative regulation of gene expression)
GO:0010718 (positive regulation of epithelial to mesenchymal transition)
GO:0010909 (positive regulation of heparan sulfate proteoglycan biosynthetic process)
GO:0014010 (Schwann cell proliferation)
GO:0014070 (response to organic cyclic compound)
GO:0014823 (response to activity)
GO:0016055 (Wnt signaling pathway)
GO:0016331 (morphogenesis of embryonic epithelium)
GO:0016337 (single organismal cell-cell adhesion)
GO:0019827 (stem cell population maintenance)
GO:0021819 (layer formation in cerebral cortex)
GO:0022009 (central nervous system vasculogenesis)
GO:0022405 (hair cycle process)
GO:0030097 (hemopoiesis)
GO:0030154 (cell differentiation)
GO:0030182 (neuron differentiation)
GO:0030217 (T cell differentiation)
GO:0030316 (osteoclast differentiation)
GO:0030324 (lung development)
GO:0030521 (androgen receptor signaling pathway)
GO:0030539 (male genitalia development)
GO:0030856 (regulation of epithelial cell differentiation)
GO:0030858 (positive regulation of epithelial cell differentiation)
GO:0030900 (forebrain development)
GO:0030901 (midbrain development)
GO:0030902 (hindbrain development)
GO:0030997 (regulation of centriole-centriole cohesion)
GO:0031016 (pancreas development)
GO:0031069 (hair follicle morphogenesis)
GO:0031641 (regulation of myelination)
GO:0032212 (positive regulation of telomere maintenance via telomerase)
GO:0032331 (negative regulation of chondrocyte differentiation)
GO:0032355 (response to estradiol)
GO:0032481 (positive regulation of type I interferon production)
GO:0033077 (T cell differentiation in thymus)
GO:0033234 (negative regulation of protein sumoylation)
GO:0034097 (response to cytokine)
GO:0034332 (adherens junction organization)
GO:0034333 (adherens junction assembly)
GO:0034394 (protein localization to cell surface)
GO:0034613 (cellular protein localization)
GO:0035050 (embryonic heart tube development)
GO:0035112 (genitalia morphogenesis)
GO:0035115 (embryonic forelimb morphogenesis)
GO:0035116 (embryonic hindlimb morphogenesis)
GO:0035315 (hair cell differentiation)
GO:0035411 (catenin import into nucleus)
GO:0036023 (embryonic skeletal limb joint morphogenesis)
GO:0042127 (regulation of cell proliferation)
GO:0042129 (regulation of T cell proliferation)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042493 (response to drug)
GO:0042733 (embryonic digit morphogenesis)
GO:0042981 (regulation of apoptotic process)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0043410 (positive regulation of MAPK cascade)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0043588 (skin development)
GO:0043627 (response to estrogen)
GO:0044334 (canonical Wnt signaling pathway involved in positive regulation of epithelial to mesenchymal transition)
GO:0044336 (canonical Wnt signaling pathway involved in negative regulation of apoptotic process)
GO:0044344 (cellular response to fibroblast growth factor stimulus)
GO:0045445 (myoblast differentiation)
GO:0045453 (bone resorption)
GO:0045595 (regulation of cell differentiation)
GO:0045596 (negative regulation of cell differentiation)
GO:0045603 (positive regulation of endothelial cell differentiation)
GO:0045667 (regulation of osteoblast differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
GO:0045670 (regulation of osteoclast differentiation)
GO:0045671 (negative regulation of osteoclast differentiation)
GO:0045743 (positive regulation of fibroblast growth factor receptor signaling pathway)
GO:0045765 (regulation of angiogenesis)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0045976 (negative regulation of mitotic cell cycle, embryonic)
GO:0046686 (response to cadmium ion)
GO:0048096 (chromatin-mediated maintenance of transcription)
GO:0048145 (regulation of fibroblast proliferation)
GO:0048469 (cell maturation)
GO:0048489 (synaptic vesicle transport)
GO:0048513 (animal organ development)
GO:0048538 (thymus development)
GO:0048599 (oocyte development)
GO:0048617 (embryonic foregut morphogenesis)
GO:0048643 (positive regulation of skeletal muscle tissue development)
GO:0048660 (regulation of smooth muscle cell proliferation)
GO:0048701 (embryonic cranial skeleton morphogenesis)
GO:0048715 (negative regulation of oligodendrocyte differentiation)
GO:0050767 (regulation of neurogenesis)
GO:0050808 (synapse organization)
GO:0051091 (positive regulation of sequence-specific DNA binding transcription factor activity)
GO:0051145 (smooth muscle cell differentiation)
GO:0051149 (positive regulation of muscle cell differentiation)
GO:0051291 (protein heterooligomerization)
GO:0051571 (positive regulation of histone H3-K4 methylation)
GO:0051973 (positive regulation of telomerase activity)
GO:0060066 (oviduct development)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060173 (limb development)
GO:0060439 (trachea morphogenesis)
GO:0060440 (trachea formation)
GO:0060441 (epithelial tube branching involved in lung morphogenesis)
GO:0060479 (lung cell differentiation)
GO:0060484 (lung-associated mesenchyme development)
GO:0060492 (lung induction)
GO:0060742 (epithelial cell differentiation involved in prostate gland development)
GO:0060769 (positive regulation of epithelial cell proliferation involved in prostate gland development)
GO:0060789 (hair follicle placode formation)
GO:0060916 (mesenchymal cell proliferation involved in lung development)
GO:0061047 (positive regulation of branching involved in lung morphogenesis)
GO:0061154 (endothelial tube morphogenesis)
GO:0061198 (fungiform papilla formation)
GO:0061324 (canonical Wnt signaling pathway involved in positive regulation of cardiac outflow tract cell proliferation)
GO:0061549 (sympathetic ganglion development)
GO:0061550 (cranial ganglion development)
GO:0070602 (regulation of centromeric sister chromatid cohesion)
GO:0071260 (cellular response to mechanical stimulus)
GO:0071285 (cellular response to lithium ion)
GO:0071363 (cellular response to growth factor stimulus)
GO:0071542 (dopaminergic neuron differentiation)
GO:0071681 (cellular response to indole-3-methanol)
GO:0072001 (renal system development)
GO:0072033 (renal vesicle formation)
GO:0072053 (renal inner medulla development)
GO:0072054 (renal outer medulla development)
GO:0072079 (nephron tubule formation)
GO:0072182 (regulation of nephron tubule epithelial cell differentiation)
GO:0090279 (regulation of calcium ion import)
GO:1901215 (negative regulation of neuron death)
GO:1904501 (positive regulation of chromatin-mediated maintenance of transcription)
GO:1904793 (regulation of euchromatin binding)
GO:1904796 (regulation of core promoter binding)
GO:1904837 (beta-catenin-TCF complex assembly)
GO:1904886 (beta-catenin destruction complex disassembly)
GO:1904948 (midbrain dopaminergic neuron differentiation)
GO:1904954 (canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation)
GO:1990314 (cellular response to insulin-like growth factor stimulus)
GO:1990403 (embryonic brain development)
GO:1990791 (dorsal root ganglion development)
GO:2000008 (regulation of protein localization to cell surface)
GO:2000017 (positive regulation of determination of dorsal identity)
GO:2000144 (positive regulation of DNA-templated transcription, initiation)
GO:2001234 (negative regulation of apoptotic signaling pathway)
Wikipedia Beta-catenin

Target Cross References - Protein

canSAR P35222
CGD Mental retardation, autosomal dominant, 19
Human Protein Atlas ENSG00000168036
IntAct P35222
Open Targets ENSG00000168036
PharmGKB PA27013
Reactome R-HSA-195253 (Degradation of beta-catenin by the destruction complex.)
R-HSA-196299 (Beta-catenin phosphorylation cascade.)
R-HSA-201681 (TCF dependent signaling in response to WNT.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-3134973 (LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.)
R-HSA-351906 (Apoptotic cleavage of cell adhesion proteins.)
R-HSA-375170 (CDO in myogenesis.)
R-HSA-3769402 (Deactivation of the beta-catenin transactivating complex.)
R-HSA-381771 (Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-418990 (Adherens junctions interactions.)
R-HSA-4411364 (Binding of TCF/LEF:CTNNB1 to target gene promoters.)
R-HSA-4641262 (Disassembly of the destruction complex and recruitment of AXIN to the membrane.)
R-HSA-5218920 (VEGFR2 mediated vascular permeability.)
R-HSA-5339716 (Misspliced GSK3beta mutants stabilize beta-catenin.)
R-HSA-5358747 (S33 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358749 (S37 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358751 (S45 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5358752 (T41 mutants of beta-catenin aren't phosphorylated.)
R-HSA-5626467 (RHO GTPases activate IQGAPs.)
R-HSA-8876493 (InlA-mediated entry of Listeria monocytogenes into host cells.)
TIMBAL Beta-catenin
UniProt A8K1L7 P35222 Q8NEW9 Q8NI94 Q9H391

Target Cross References - Domain

InterPro IPR000225 (Armadillo.)
IPR011989 (ARM-like.)
IPR013284 (Beta-catenin.)
IPR016024 (ARM-type_fold.)
Pfam PF00514 (Arm)

Target Cross References - Structure

PDBe 1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS
CREDO 1G3J 1JDH 1JPW 1LUJ 1P22 1QZ7 1T08 1TH1 2GL7 2Z6H 3DIW 3FQN 3FQR 3SL9 3SLA 3TX7 4DJS