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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5861
Target Type SINGLE PROTEIN
Preferred Name G protein-coupled receptor kinase 4
Synonyms G protein-coupled receptor kinase 4 | G protein-coupled receptor kinase GRK4 | GPRK2L | GPRK4 | GRK4 | ITI1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase grk subfamily

Target Components

Component Description Relationship Accession
G protein-coupled receptor kinase 4 SINGLE PROTEIN P32298

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000125388
Ensembl ENSG00000125388
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005938 (cell cortex)
GO:0030425 (dendrite)
GO:0043025 (neuronal cell body)
GO:0097381 (photoreceptor disc membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0050254 (rhodopsin kinase activity)
GO Biological Process GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0002031 (G-protein coupled receptor internalization)
GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0008277 (regulation of G-protein coupled receptor protein signaling pathway)
GO:0016310 (phosphorylation)
GO:0022400 (regulation of rhodopsin mediated signaling pathway)
GO:0031623 (receptor internalization)
Wikipedia GRK4

Target Cross References - Protein

canSAR P32298
Human Protein Atlas ENSG00000125388
IntAct P32298
Guide to Pharmacology 1468
Open Targets ENSG00000125388
PharmGKB PA28941
Pharos P32298 (Tchem)
Reactome R-HSA-2514859 (Inactivation, recovery and regulation of the phototransduction cascade.)
UniProt O00641 O00642 P32298 Q13293 Q13294 Q13295 Q14453 Q14725 Q15313 Q15314 Q15315 Q15316 Q17RH6 Q53EQ8

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR016137 (RGS.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
PF00615 (RGS)

Target Cross References - Structure

PDBe 4YHJ
CREDO 4YHJ
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