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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5845
Target Type SINGLE PROTEIN
Preferred Name Glycine receptor subunit alpha-1
Synonyms GLRA1 | Glycine receptor 48 kDa subunit | Glycine receptor strychnine-binding subunit | Glycine receptor subunit alpha-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • ion channel > ligand-gated ion channel > glycine receptor

Target Components

Component Description Relationship Accession
Glycine receptor subunit alpha-1 SINGLE PROTEIN P23415

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363052 Glycine receptor (alpha-1/beta) PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000145888
Ensembl ENSG00000145888
GO Cellular Component GO:0005622 (intracellular)
GO:0005783 (endoplasmic reticulum)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0030054 (cell junction)
GO:0030425 (dendrite)
GO:0034707 (chloride channel complex)
GO:0042995 (cell projection)
GO:0043005 (neuron projection)
GO:0043025 (neuronal cell body)
GO:0043204 (perikaryon)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0060077 (inhibitory synapse)
GO Molecular Function GO:0005230 (extracellular ligand-gated ion channel activity)
GO:0005254 (chloride channel activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0016594 (glycine binding)
GO:0016933 (extracellular-glycine-gated ion channel activity)
GO:0016934 (extracellular-glycine-gated chloride channel activity)
GO:0022824 (transmitter-gated ion channel activity)
GO:0030977 (taurine binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0001508 (action potential)
GO:0001964 (startle response)
GO:0002087 (regulation of respiratory gaseous exchange by neurological system process)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006820 (anion transport)
GO:0006821 (chloride transport)
GO:0006936 (muscle contraction)
GO:0007218 (neuropeptide signaling pathway)
GO:0007268 (chemical synaptic transmission)
GO:0007340 (acrosome reaction)
GO:0007601 (visual perception)
GO:0007628 (adult walking behavior)
GO:0034220 (ion transmembrane transport)
GO:0042391 (regulation of membrane potential)
GO:0043576 (regulation of respiratory gaseous exchange)
GO:0050884 (neuromuscular process controlling posture)
GO:0050905 (neuromuscular process)
GO:0051260 (protein homooligomerization)
GO:0051291 (protein heterooligomerization)
GO:0051970 (negative regulation of transmission of nerve impulse)
GO:0060012 (synaptic transmission, glycinergic)
GO:0060013 (righting reflex)
GO:0060080 (inhibitory postsynaptic potential)
GO:0071230 (cellular response to amino acid stimulus)
GO:0071294 (cellular response to zinc ion)
GO:0071361 (cellular response to ethanol)
GO:0097305 (response to alcohol)
GO:1902476 (chloride transmembrane transport)
GO:2000344 (positive regulation of acrosome reaction)
Wikipedia Glycine_receptor,_alpha_1

Target Cross References - Protein

canSAR P23415
CGD Hyperekplexia, hereditary
Human Protein Atlas ENSG00000145888
IntAct P23415
Guide to Pharmacology 423
Open Targets ENSG00000145888
PharmGKB PA28727
Pharos P23415 (Tclin)
Reactome R-HSA-975298 (Ligand-gated ion channel transport.)
UniProt B2R6T3 P23415 Q14C77 Q6DJV9

Target Cross References - Domain

InterPro IPR006028 (GABAA/Glycine_rcpt.)
IPR006029 (Neurotrans-gated_channel_TM.)
IPR006201 (Neur_channel.)
IPR006202 (Neur_chan_lig-bd.)
IPR008127 (Glycine_rcpt_A.)
IPR008128 (Glycine_rcpt_A1.)
IPR018000 (Neurotransmitter_ion_chnl_CS.)
Pfam PF02931 (Neur_chan_LBD)
PF02932 (Neur_chan_memb)

Target Cross References - Structure

PDBe 4X5T
CREDO 4X5T
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