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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5842
Preferred Name Low affinity immunoglobulin gamma Fc region receptor III-B
Synonyms CD16B | CD_antigen=CD16b | FCG3 | FCGR3 | FCGR3B | Fc-gamma RIII | Fc-gamma RIII-beta | Fc-gamma RIIIb | FcR-10 | FcRIII | FcRIIIb | IGFR3 | IgG Fc receptor III-1 | Low affinity immunoglobulin gamma Fc region receptor III-B
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Low affinity immunoglobulin gamma Fc region receptor III-B SINGLE PROTEIN O75015

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000162747
Ensembl ENSG00000162747
GO Cellular Component GO:0005576 (extracellular region)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0031225 (anchored component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0019864 (IgG binding)
GO Biological Process GO:0002230 (positive regulation of defense response to virus by host)
GO:0006955 (immune response)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
GO:0098792 (xenophagy)
Wikipedia FCGR3B

Target Cross References - Protein

canSAR O75015
Human Protein Atlas ENSG00000162747
IntAct O75015
Open Targets ENSG00000162747
PharmGKB PA28066
Reactome R-HSA-163125 (Post-translational modification: synthesis of GPI-anchored proteins.)
R-HSA-6798695 (Neutrophil degranulation.)
UniProt O75015

Target Cross References - Domain

InterPro IPR003599 (Ig_sub.)
IPR007110 (Ig-like_dom.)
IPR013783 (Ig-like_fold.)
Pfam PF13895 (Ig_2)

Target Cross References - Structure

PDBe 1E4J 1E4K 1FNL 1T83 1T89
CREDO 1E4J 1E4K 1FNL 1T83 1T89