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Target Report Card

Target Name and Classification

Target ID CHEMBL5840
Preferred Name Fatty acid desaturase 1
Synonyms D5D | Delta(5) desaturase | Delta(5) fatty acid desaturase | Delta-5 desaturase | FADS1 | FADSD5 | Fatty acid desaturase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Fatty acid desaturase 1 SINGLE PROTEIN O60427

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000149485
Ensembl ENSG00000149485
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005783 (endoplasmic reticulum)
GO:0005789 (endoplasmic reticulum membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0000248 (C-5 sterol desaturase activity)
GO:0016491 (oxidoreductase activity)
GO:0045485 (omega-6 fatty acid desaturase activity)
GO Biological Process GO:0006355 (regulation of transcription, DNA-templated)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006633 (fatty acid biosynthetic process)
GO:0006636 (unsaturated fatty acid biosynthetic process)
GO:0007267 (cell-cell signaling)
GO:0008654 (phospholipid biosynthetic process)
GO:0009267 (cellular response to starvation)
GO:0036109 (alpha-linolenic acid metabolic process)
GO:0043651 (linoleic acid metabolic process)
GO:0045595 (regulation of cell differentiation)
GO:0046456 (icosanoid biosynthetic process)
GO:0055114 (oxidation-reduction process)
Wikipedia FADS1

Target Cross References - Protein

canSAR O60427
Human Protein Atlas ENSG00000149485
IntAct O60427
Open Targets ENSG00000149485
PharmGKB PA27973
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2046105 (Linoleic acid (LA) metabolism.)
R-HSA-2046106 (alpha-linolenic acid (ALA) metabolism.)
UniProt A8K0I7 B2RAI0 O60427 Q53GM5 Q8N3A6 Q8NCC7 Q8NCG0 Q96I39 Q96SV3 Q96T10 Q9NRP8 Q9NYX1

Target Cross References - Domain

InterPro IPR001199 (Cyt_B5-like_heme/steroid-bd.)
IPR005804 (FA_desaturase_dom.)
IPR012171 (Fatty_acid_desaturase.)
Pfam PF00173 (Cyt-b5)
PF00487 (FA_desaturase)