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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5838
Target Type SINGLE PROTEIN
Preferred Name Receptor tyrosine-protein kinase erbB-3
Synonyms ERBB3 | HER3 | Proto-oncogene-like protein c-ErbB-3 | Receptor tyrosine-protein kinase erbB-3 | Tyrosine kinase-type cell surface receptor HER3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase egfr family

Target Components

Component Description Relationship Accession
Receptor tyrosine-protein kinase erbB-3 SINGLE PROTEIN P21860

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363049 Epidermal growth factor receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2109406 Patritumab Receptor tyrosine-protein kinase erbB-3 inhibitor 3
CHEMBL2109402 MM-121 Receptor tyrosine-protein kinase erbB-3 antagonist 2 PubMed
CHEMBL2408045 SAPITINIB Receptor tyrosine-protein kinase erbB-3 inhibitor 2 PubMed PubMed

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065361
Ensembl ENSG00000065361
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0016328 (lateral plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0030296 (protein tyrosine kinase activator activity)
GO:0038132 (neuregulin binding)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0003197 (endocardial cushion development)
GO:0006468 (protein phosphorylation)
GO:0007162 (negative regulation of cell adhesion)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007422 (peripheral nervous system development)
GO:0007507 (heart development)
GO:0009968 (negative regulation of signal transduction)
GO:0014037 (Schwann cell differentiation)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021545 (cranial nerve development)
GO:0038128 (ERBB2 signaling pathway)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0043547 (positive regulation of GTPase activity)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0051048 (negative regulation of secretion)
GO:0051402 (neuron apoptotic process)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0070886 (positive regulation of calcineurin-NFAT signaling cascade)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2000145 (regulation of cell motility)
Wikipedia ERBB3

Target Cross References - Protein

canSAR P21860
CGD Lethal congenital contractural syndrome 2
Human Protein Atlas ENSG00000065361
IntAct P21860
Guide to Pharmacology 1798
Open Targets ENSG00000065361
PharmGKB PA27846
Pharos P21860 (Tchem)
Reactome R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1236394 (Signaling by ERBB4.)
R-HSA-1250196 (SHC1 events in ERBB2 signaling.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-1306955 (GRB7 events in ERBB2 signaling.)
R-HSA-1358803 (Downregulation of ERBB2:ERBB3 signaling.)
R-HSA-1963642 (PI3K events in ERBB2 signaling.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6785631 (ERBB2 Regulates Cell Motility.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8847993 (ERBB2 Activates PTK6 Signaling.)
R-HSA-8863795 (Downregulation of ERBB2 signaling.)
UniProt A8K6L6 B4DIK7 B4DV32 E9PDT8 P21860 Q9BUD7

Target Cross References - Domain

InterPro IPR000494 (Rcpt_L-dom.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR006211 (Furin-like_Cys-rich_dom.)
IPR006212 (Furin_repeat.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR016245 (Tyr_kinase_EGF/ERB/XmrK_rcpt.)
IPR032675 (L_dom-like.)
IPR032778 (GF_recep_IV.)
Pfam PF00757 (Furin-like)
PF01030 (Recep_L_domain)
PF07714 (Pkinase_Tyr)
PF14843 (GF_recep_IV)

Target Cross References - Structure

PDBe 1M6B 3KEX 3LMG 3P11 4LEO 4OTW 4P59 4RIW 4RIX 4RIY 5CUS
CREDO 1M6B 3KEX 3LMG 3P11 4LEO 4OTW 4P59 4RIW 4RIX 4RIY 5CUS
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