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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5838
Target Type SINGLE PROTEIN
Preferred Name Receptor tyrosine-protein kinase erbB-3
Synonyms ERBB3 | HER3 | Proto-oncogene-like protein c-ErbB-3 | Receptor tyrosine-protein kinase erbB-3 | Tyrosine kinase-type cell surface receptor HER3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase egfr family

Target Components

Component Description Relationship Accession
Receptor tyrosine-protein kinase erbB-3 SINGLE PROTEIN P21860

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363049 Epidermal growth factor receptor PROTEIN FAMILY

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2408045 SAPITINIB Receptor tyrosine-protein kinase erbB-3 inhibitor 2

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000065361
Ensembl ENSG00000065361
GO Cellular Component GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005887 (integral to plasma membrane)
GO:0016323 (basolateral plasma membrane)
GO:0016324 (apical plasma membrane)
GO:0016328 (lateral plasma membrane)
GO:0043235 (receptor complex)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0004716 (receptor signaling protein tyrosine kinase activity)
GO:0004888 (transmembrane signaling receptor activity)
GO:0005524 (ATP binding)
GO:0019838 (growth factor binding)
GO:0030296 (protein tyrosine kinase activator activity)
GO:0042802 (identical protein binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0003197 (endocardial cushion development)
GO:0006468 (protein phosphorylation)
GO:0007162 (negative regulation of cell adhesion)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007264 (small GTPase mediated signal transduction)
GO:0007265 (Ras protein signal transduction)
GO:0007411 (axon guidance)
GO:0007422 (peripheral nervous system development)
GO:0007507 (heart development)
GO:0008286 (insulin receptor signaling pathway)
GO:0008543 (fibroblast growth factor receptor signaling pathway)
GO:0009968 (negative regulation of signal transduction)
GO:0014037 (Schwann cell differentiation)
GO:0014065 (phosphatidylinositol 3-kinase cascade)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase cascade)
GO:0014068 (positive regulation of phosphatidylinositol 3-kinase signaling)
GO:0021545 (cranial nerve development)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042060 (wound healing)
GO:0042127 (regulation of cell proliferation)
GO:0043524 (negative regulation of neuron apoptosis)
GO:0043524 (negative regulation of neuron apoptotic process)
GO:0045087 (innate immune response)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048011 (neurotrophin TRK receptor signaling pathway)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0051048 (negative regulation of secretion)
GO:0051402 (neuron apoptosis)
GO:0051402 (neuron apoptotic process)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0070886 (positive regulation of calcineurin-NFAT signaling cascade)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
Wikipedia ERBB3

Target Cross References - Protein

canSAR P21860
CGD Lethal congenital contractural syndrome 2
Human Protein Atlas ENSG00000065361
IntAct P21860
PharmGKB PA27846
UniProt A8K6L6 B4DIK7 B4DV32 E9PDT8 P21860 Q9BUD7

Target Cross References - Domain

InterPro IPR000494 (EGF_rcpt_L.)
IPR000494 (Rcpt_L-dom.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR006211 (Furin-like_Cys-rich_dom.)
IPR006212 (Furin_repeat.)
IPR009030 (Growth_fac_rcpt.)
IPR009030 (Growth_fac_rcpt_N_dom.)
IPR011009 (Kinase-like_dom.)
IPR016245 (Tyr_kinase_EGF/ERB/XmrK_rcpt.)
IPR020635 (Tyr_Pkinase_cat_dom.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF00757 (Furin-like)
PF01030 (Recep_L_domain)
PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 1M6B 3KEX 3LMG 3P11 4LEO 4OTW 4P59 4RIW 4RIX 4RIY 5CUS
CREDO 1M6B 3KEX 3LMG 3P11 4LEO 4OTW 4P59 4RIW 4RIX 4RIY 5CUS
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