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Target Report Card

Target Name and Classification

Target ID CHEMBL5837
Target Type SINGLE PROTEIN
Preferred Name Erythropoietin
Synonyms EPO | Erythropoietin | INN=Epoetin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Erythropoietin SINGLE PROTEIN P01588

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130427
Ensembl ENSG00000130427
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0009986 (cell surface)
GO Molecular Function GO:0005128 (erythropoietin receptor binding)
GO:0005179 (hormone activity)
GO:0005515 (protein binding)
GO:0030295 (protein kinase activator activity)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006915 (apoptotic process)
GO:0006953 (acute-phase response)
GO:0007165 (signal transduction)
GO:0007566 (embryo implantation)
GO:0007568 (aging)
GO:0007584 (response to nutrient)
GO:0008015 (blood circulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0009651 (response to salt stress)
GO:0010523 (negative regulation of calcium ion transport into cytosol)
GO:0010976 (positive regulation of neuron projection development)
GO:0018105 (peptidyl-serine phosphorylation)
GO:0030218 (erythrocyte differentiation)
GO:0032147 (activation of protein kinase activity)
GO:0032496 (response to lipopolysaccharide)
GO:0033033 (negative regulation of myeloid cell apoptotic process)
GO:0033189 (response to vitamin A)
GO:0033574 (response to testosterone)
GO:0042104 (positive regulation of activated T cell proliferation)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
GO:0042541 (hemoglobin biosynthetic process)
GO:0043066 (negative regulation of apoptotic process)
GO:0043249 (erythrocyte maturation)
GO:0043627 (response to estrogen)
GO:0045666 (positive regulation of neuron differentiation)
GO:0045740 (positive regulation of DNA replication)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046579 (positive regulation of Ras protein signal transduction)
GO:0048678 (response to axon injury)
GO:0051602 (response to electrical stimulus)
GO:0055093 (response to hyperoxia)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070555 (response to interleukin-1)
GO:0071474 (cellular hyperosmotic response)
GO:1901215 (negative regulation of neuron death)
GO:1902219 (negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress)
GO:1902251 (negative regulation of erythrocyte apoptotic process)
GO:2001258 (negative regulation of cation channel activity)
Wikipedia Erythropoietin

Target Cross References - Protein

canSAR P01588
Human Protein Atlas ENSG00000130427
IntAct P01588
Open Targets ENSG00000130427
PharmGKB PA27833
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
UniProt P01588 Q2M2L6 Q549U2 Q9UDZ0 Q9UEZ5 Q9UHA0

Target Cross References - Domain

InterPro IPR001323 (EPO_TPO.)
IPR003013 (Erythroptn.)
IPR009079 (4_helix_cytokine-like_core.)
IPR012351 (4_helix_cytokine_core.)
IPR019767 (EPO/TPO_CS.)
Pfam PF00758 (EPO_TPO)

Target Cross References - Structure

PDBe 1CN4 1EER
CREDO 1CN4 1EER
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