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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5837
Target Type SINGLE PROTEIN
Preferred Name Erythropoietin
Synonyms EPO | Erythropoietin | INN=Epoetin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Erythropoietin SINGLE PROTEIN P01588

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000130427
Ensembl ENSG00000130427
GO Cellular Component GO:0005615 (extracellular space)
GO Molecular Function GO:0005128 (erythropoietin receptor binding)
GO:0005179 (hormone activity)
GO:0043499 (eukaryotic cell surface binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0008015 (blood circulation)
GO:0008284 (positive regulation of cell proliferation)
GO:0010766 (negative regulation of sodium ion transport)
GO:0032413 (negative regulation of ion transmembrane transporter activity)
GO:0042523 (positive regulation of tyrosine phosphorylation of Stat5 protein)
GO:0043066 (negative regulation of apoptosis)
GO:0043249 (erythrocyte maturation)
GO:0045740 (positive regulation of DNA replication)
GO:0045893 (positive regulation of transcription, DNA-dependent)
GO:0046579 (positive regulation of Ras protein signal transduction)
GO:0071474 (cellular hyperosmotic response)
Wikipedia Erythropoietin

Target Cross References - Protein

canSAR P01588
Human Protein Atlas ENSG00000130427
IntAct P01588
PharmGKB PA27833
UniProt P01588 Q2M2L6 Q549U2 Q9UDZ0 Q9UEZ5 Q9UHA0

Target Cross References - Domain

InterPro IPR001323 (EPO_TPO.)
IPR003013 (Erythroptn.)
IPR009079 (4_helix_cytokine-like_core.)
IPR012351 (4_helix_cytokine_core.)
IPR019767 (EPO/TPO_CS.)
Pfam PF00758 (EPO_TPO)

Target Cross References - Structure

PDBe 1CN4 1EER
CREDO 1CN4 1EER
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