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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5836
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-B receptor 6
Synonyms EPHB6 | Ephrin type-B receptor 6 | HEP | Tyrosine-protein kinase-defective receptor EPH-6
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Ephrin type-B receptor 6 SINGLE PROTEIN O15197

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000106123
Ensembl ENSG00000106123
GO Cellular Component GO:0005576 (extracellular region)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004872 (receptor activity)
GO:0005003 (ephrin receptor activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0048013 (ephrin receptor signaling pathway)
Wikipedia EPHB6

Target Cross References - Protein

canSAR O15197
Human Protein Atlas ENSG00000106123
IntAct O15197
Guide to Pharmacology 1834
Open Targets ENSG00000106123
PharmGKB PA27828
Pharos O15197 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-3928662 (EPHB-mediated forward signaling.)
R-HSA-3928664 (Ephrin signaling.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt A4D2I7 A8CDT5 D3DXD3 O15197 Q2TB23 Q2TB24

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008979 (Galactose-bd-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR027936 (Eph_TM.)
Pfam PF00041 (fn3)
PF01404 (Ephrin_lbd)
PF07647 (SAM_2)
PF07699 (Ephrin_rec_like)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)
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