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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5815
Target Type SINGLE PROTEIN
Preferred Name C-C chemokine receptor type 9
Synonyms C-C CKR-9 | C-C chemokine receptor type 9 | CC-CKR-9 | CCR-9 | CCR9 | CD_antigen=CDw199 | G-protein coupled receptor 28 | GPR-9-6 | GPR28
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > family a g protein-coupled receptor > peptide receptor (family a gpcr) > chemokine receptor > cc chemokine receptor

Target Components

Component Description Relationship Accession
C-C chemokine receptor type 9 SINGLE PROTEIN P51686

Approved Drugs and Clinical Candidates

ChEMBL ID Name Mechanism of Action Max Phase References
CHEMBL2178578 VERCIRNON C-C chemokine receptor type 9 antagonist 3 PubMed
CHEMBL3545268 MLN3126 C-C chemokine receptor type 9 antagonist 1 Other

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000173585
Ensembl ENSG00000173585
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0004871 (signal transducer activity)
GO:0004930 (G-protein coupled receptor activity)
GO:0004950 (chemokine receptor activity)
GO:0016493 (C-C chemokine receptor activity)
GO Biological Process GO:0002305 (CD8-positive, gamma-delta intraepithelial T cell differentiation)
GO:0006935 (chemotaxis)
GO:0006955 (immune response)
GO:0006968 (cellular defense response)
GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0070098 (chemokine-mediated signaling pathway)
Wikipedia CCR9

Target Cross References - Protein

canSAR P51686
Human Protein Atlas ENSG00000173585
Guide to Pharmacology 66
Open Targets ENSG00000173585
PharmGKB PA26174
Pharos P51686 (Tchem)
Reactome R-HSA-380108 (Chemokine receptors bind chemokines.)
R-HSA-418594 (G alpha (i) signalling events.)
UniProt P51686 Q4VBM3 Q549E0 Q9UQQ6

Target Cross References - Domain

InterPro IPR000276 (GPCR_Rhodpsn.)
IPR000355 (Chemokine_rcpt.)
IPR004069 (Chemokine_CCR9.)
IPR017452 (GPCR_Rhodpsn_7TM.)
Pfam PF00001 (7tm_1)

Target Cross References - Structure

PDBe 5LWE
CREDO 5LWE
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