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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5814
Target Type SINGLE PROTEIN
Preferred Name Peroxisomal multifunctional enzyme type 2
Synonyms (3R)-hydroxyacyl-CoA dehydrogenase | 17-beta-HSD 4 | 17-beta-hydroxysteroid dehydrogenase 4 | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase | D-bifunctional protein | DBP | EDH17B4 | Enoyl-CoA hydratase 2 | HSD17B4 | MFE-2 | MPF-2 | Multifunctional protein 2 | Peroxisomal multifunctional enzyme type 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peroxisomal multifunctional enzyme type 2 SINGLE PROTEIN P51659

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133835
Ensembl ENSG00000133835
GO Cellular Component GO:0005782 (peroxisomal matrix)
GO Molecular Function GO:0003857 (3-hydroxyacyl-CoA dehydrogenase activity)
GO:0004303 (estradiol 17-beta-dehydrogenase activity)
GO:0005515 (protein binding)
GO:0015248 (sterol transporter activity)
GO:0016508 (long-chain-enoyl-CoA hydratase activity)
GO:0016853 (isomerase activity)
GO:0032934 (sterol binding)
GO:0033989 (3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)
GO Biological Process GO:0006699 (bile acid biosynthetic process)
GO:0033540 (fatty acid beta-oxidation using acyl-CoA oxidase)
Wikipedia HSD17B4

Target Cross References - Protein

canSAR P51659
CGD Perrault syndrome
Human Protein Atlas ENSG00000133835
IntAct P51659
PharmGKB PA29481
Reactome REACT_22258 (Metabolism of lipids and lipoproteins.)
UniProt P51659

Target Cross References - Domain

InterPro IPR002198 (DH_sc/Rdtase_SDR.)
IPR002347 (Glc/ribitol_DH.)
IPR002539 (MaoC_deHydtase.)
IPR003033 (SCP2_sterol-bd_dom.)
IPR016040 (NAD(P)-bd_dom.)
IPR020904 (Sc_DH/Rdtase_CS.)
Pfam PF00106 (adh_short)
PF01575 (MaoC_dehydratas)
PF02036 (SCP2)

Target Cross References - Structure

PDBe 1IKT 1S9C 1ZBQ
CREDO 1IKT 1S9C 1ZBQ
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