ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5814
Target Type SINGLE PROTEIN
Preferred Name Peroxisomal multifunctional enzyme type 2
Synonyms (3R)-hydroxyacyl-CoA dehydrogenase | 17-beta-HSD 4 | 17-beta-hydroxysteroid dehydrogenase 4 | 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase | D-bifunctional protein | DBP | EDH17B4 | Enoyl-CoA hydratase 2 | HSD17B4 | MFE-2 | MPF-2 | Multifunctional protein 2 | Peroxisomal multifunctional enzyme type 2 | SDR8C1 | Short chain dehydrogenase/reductase family 8C member 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Peroxisomal multifunctional enzyme type 2 SINGLE PROTEIN P51659

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133835
Ensembl ENSG00000133835
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005777 (peroxisome)
GO:0005778 (peroxisomal membrane)
GO:0005782 (peroxisomal matrix)
GO:0016020 (membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003857 (3-hydroxyacyl-CoA dehydrogenase activity)
GO:0005102 (receptor binding)
GO:0016491 (oxidoreductase activity)
GO:0016508 (long-chain-enoyl-CoA hydratase activity)
GO:0016616 (oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor)
GO:0016829 (lyase activity)
GO:0016853 (isomerase activity)
GO:0033989 (3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase activity)
GO:0042803 (protein homodimerization activity)
GO:0044594 (17-beta-hydroxysteroid dehydrogenase (NAD+) activity)
GO Biological Process GO:0000038 (very long-chain fatty acid metabolic process)
GO:0001649 (osteoblast differentiation)
GO:0006629 (lipid metabolic process)
GO:0006631 (fatty acid metabolic process)
GO:0006635 (fatty acid beta-oxidation)
GO:0006699 (bile acid biosynthetic process)
GO:0008209 (androgen metabolic process)
GO:0008210 (estrogen metabolic process)
GO:0033540 (fatty acid beta-oxidation using acyl-CoA oxidase)
GO:0036109 (alpha-linolenic acid metabolic process)
GO:0036111 (very long-chain fatty-acyl-CoA metabolic process)
GO:0036112 (medium-chain fatty-acyl-CoA metabolic process)
GO:0055114 (oxidation-reduction process)
GO:0060009 (Sertoli cell development)
Wikipedia HSD17B4

Target Cross References - Protein

canSAR P51659
CGD Perrault syndrome
Human Protein Atlas ENSG00000133835
IntAct P51659
Open Targets ENSG00000133835
PharmGKB PA29481
Reactome R-HSA-193368 (Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol.)
R-HSA-2046106 (alpha-linolenic acid (ALA) metabolism.)
R-HSA-389887 (Beta-oxidation of pristanoyl-CoA.)
R-HSA-390247 (Beta-oxidation of very long chain fatty acids.)
UniProt B4DNV1 B4DVS5 E9PB82 F5HE57 P51659

Target Cross References - Domain

InterPro IPR002347 (SDR_fam.)
IPR002539 (MaoC_dom.)
IPR003033 (SCP2_sterol-bd_dom.)
IPR016040 (NAD(P)-bd_dom.)
IPR020904 (Sc_DH/Rdtase_CS.)
IPR029069 (HotDog_dom.)
Pfam PF00106 (adh_short)
PF01575 (MaoC_dehydratas)
PF02036 (SCP2)

Target Cross References - Structure

PDBe 1IKT 1S9C 1ZBQ
CREDO 1IKT 1S9C 1ZBQ
spacer
spacer