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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5813
Target Type SINGLE PROTEIN
Preferred Name Tumor necrosis factor ligand superfamily member 10
Synonyms APO2L | Apo-2 ligand | Apo-2L | CD_antigen=CD253 | Protein TRAIL | TNF-related apoptosis-inducing ligand | TNFSF10 | TRAIL | Tumor necrosis factor ligand superfamily member 10
Organism Homo sapiens
Species Group No
Protein Target Classification
  • secreted protein

Target Components

Component Description Relationship Accession
Tumor necrosis factor ligand superfamily member 10 SINGLE PROTEIN P50591

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121858
Ensembl ENSG00000121858
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005125 (cytokine activity)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0032813 (tumor necrosis factor receptor superfamily binding)
GO:0042802 (identical protein binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0008584 (male gonad development)
GO:0010469 (regulation of receptor activity)
GO:0032868 (response to insulin)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:2001238 (positive regulation of extrinsic apoptotic signaling pathway)
Wikipedia TRAIL

Target Cross References - Protein

canSAR P50591
Human Protein Atlas ENSG00000121858
IntAct P50591
Open Targets ENSG00000121858
PharmGKB PA36618
Reactome R-HSA-140534 (Ligand-dependent caspase activation.)
R-HSA-3371378 (Regulation by c-FLIP.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5218900 (CASP8 activity is inhibited.)
R-HSA-69416 (Dimerization of procaspase-8.)
R-HSA-75158 (TRAIL signaling.)
UniProt A1Y9B3 P50591

Target Cross References - Domain

InterPro IPR006052 (TNF_dom.)
IPR008983 (Tumour_necrosis_fac-like_dom.)
IPR017355 (TNF_ligand_10/11.)
IPR021184 (TNF_CS.)
Pfam PF00229 (TNF)

Target Cross References - Structure

PDBe 1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
CREDO 1D0G 1D2Q 1D4V 1DG6 1DU3 4N90 5CIR
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