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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5810
Target Type SINGLE PROTEIN
Preferred Name Ephrin type-A receptor 1
Synonyms EPH | EPH tyrosine kinase 1 | EPH tyrosine kinase | EPHA1 | EPHT | EPHT1 | Ephrin type-A receptor 1 | Erythropoietin-producing hepatoma receptor | Tyrosine-protein kinase receptor EPH | hEpha1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase eph family

Target Components

Component Description Relationship Accession
Ephrin type-A receptor 1 SINGLE PROTEIN P21709

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL2363043 Ephrin receptor PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000146904
Ensembl ENSG00000146904
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005003 (ephrin receptor activity)
GO:0005005 (transmembrane-ephrin receptor activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0001525 (angiogenesis)
GO:0001954 (positive regulation of cell-matrix adhesion)
GO:0006468 (protein phosphorylation)
GO:0006469 (negative regulation of protein kinase activity)
GO:0007155 (cell adhesion)
GO:0007166 (cell surface receptor signaling pathway)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0030335 (positive regulation of cell migration)
GO:0030336 (negative regulation of cell migration)
GO:0034446 (substrate adhesion-dependent cell spreading)
GO:0035019 (somatic stem cell population maintenance)
GO:0043087 (regulation of GTPase activity)
GO:0045766 (positive regulation of angiogenesis)
GO:0046777 (protein autophosphorylation)
GO:0048013 (ephrin receptor signaling pathway)
GO:0051496 (positive regulation of stress fiber assembly)
GO:0090630 (activation of GTPase activity)
Wikipedia EPH_receptor_A1

Target Cross References - Protein

Human Protein Atlas ENSG00000146904
IntAct P21709
Guide to Pharmacology 1821
Open Targets ENSG00000146904
PharmGKB PA27817
Pharos P21709 (Tchem)
Reactome R-HSA-2682334 (EPH-Ephrin signaling.)
R-HSA-2892247 (POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation.)
R-HSA-3928663 (EPHA-mediated growth cone collapse.)
R-HSA-3928665 (EPH-ephrin mediated repulsion of cells.)
UniProt A1L3V3 B5A966 B5A967 P21709 Q15405

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001090 (Ephrin_rcpt_lig-bd_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR001426 (Tyr_kinase_rcpt_V_CS.)
IPR001660 (SAM.)
IPR003961 (FN3_dom.)
IPR008266 (Tyr_kinase_AS.)
IPR008979 (Galactose-bd-like.)
IPR009030 (Growth_fac_rcpt_.)
IPR011009 (Kinase-like_dom.)
IPR011641 (Tyr-kin_ephrin_A/B_rcpt-like.)
IPR013761 (SAM/pointed.)
IPR013783 (Ig-like_fold.)
IPR016257 (Tyr_kinase_ephrin_rcpt.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
IPR027936 (Eph_TM.)
Pfam PF00041 (fn3)
PF00536 (SAM_1)
PF01404 (Ephrin_lbd)
PF07714 (Pkinase_Tyr)
PF14575 (EphA2_TM)

Target Cross References - Structure

PDBe 3HIL 3KKA
CREDO 3HIL 3KKA
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