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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5808
Target Type SINGLE PROTEIN
Preferred Name PITSLRE serine/threonine-protein kinase CDC2L1
Synonyms CDC2L1 | CDK11 | CDK11B | CLK-1 | Cell division cycle 2-like protein kinase 1 | Cell division protein kinase 11B | Cyclin-dependent kinase 11B | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLREA | PK58 | p58 CLK-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pitslre subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 11B SINGLE PROTEIN P21127

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000008128
Ensembl ENSG00000008128
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0006355 (regulation of transcription, DNA-dependent)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptosis)
GO:0006915 (apoptotic process)
GO:0007067 (mitosis)
GO:0007067 (mitotic nuclear division)
GO:0008283 (cell proliferation)
GO:0050684 (regulation of mRNA processing)
Wikipedia CDC2L1

Target Cross References - Protein

canSAR P21127
Human Protein Atlas ENSG00000008128
IntAct P21127
PharmGKB PA26262
UniProt O95265 P21127 Q12817 Q12818 Q12819 Q12820 Q12822 Q8N530 Q9NZS5 Q9UBJ0 Q9UBQ1 Q9UBR0 Q9UNY2 Q9UP57 Q9UP58 Q9UP59

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
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