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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5808
Target Type SINGLE PROTEIN
Preferred Name PITSLRE serine/threonine-protein kinase CDC2L1
Synonyms CDC2L1 | CDK11 | CDK11B | CLK-1 | Cell division cycle 2-like protein kinase 1 | Cell division protein kinase 11B | Cyclin-dependent kinase 11B | Galactosyltransferase-associated protein kinase p58/GTA | PITSLRE serine/threonine-protein kinase CDC2L1 | PITSLREA | PK58 | p58 CLK-1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase pitslre subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 11B SINGLE PROTEIN P21127

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0044822 (poly(A) RNA binding)
GO Biological Process GO:0001558 (regulation of cell growth)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007049 (cell cycle)
GO:0007067 (mitotic nuclear division)
GO:0008283 (cell proliferation)
GO:0016310 (phosphorylation)
GO:0050684 (regulation of mRNA processing)
GO:0051726 (regulation of cell cycle)
Wikipedia CDC2L1

Target Cross References - Protein

canSAR P21127
IntAct P21127
Guide to Pharmacology 1964
Open Targets
PharmGKB PA26262
Pharos P21127 (Tbio)
Reactome R-HSA-380270 (Recruitment of mitotic centrosome proteins and complexes.)
UniProt O95265 P21127 Q12817 Q12818 Q12819 Q12820 Q12822 Q8N530 Q9NZS5 Q9UBJ0 Q9UBQ1 Q9UBR0 Q9UNY2 Q9UP57 Q9UP58 Q9UP59

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
Pfam PF00069 (Pkinase)
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