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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5805
Target Type SINGLE PROTEIN
Preferred Name Toll-like receptor 8
Synonyms CD_antigen=CD288 | TLR8 | Toll-like receptor 8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 8 SINGLE PROTEIN Q9NR97

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3137288 TLR7 and TLR8 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101916
Ensembl ENSG00000101916
GO Cellular Component GO:0010008 (endosome membrane)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003725 (double-stranded RNA binding)
GO:0003727 (single-stranded RNA binding)
GO:0004888 (transmembrane receptor activity)
GO Biological Process GO:0006954 (inflammatory response)
GO:0007249 (I-kappaB kinase/NF-kappaB cascade)
GO:0016064 (immunoglobulin mediated immune response)
GO:0045078 (positive regulation of interferon-gamma biosynthetic process)
GO:0045087 (innate immune response)
GO:0045089 (positive regulation of innate immune response)
GO:0045356 (positive regulation of interferon-alpha biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0051607 (defense response to virus)
GO:0071260 (cellular response to mechanical stimulus)
Wikipedia TLR8

Target Cross References - Protein

canSAR Q9NR97
Human Protein Atlas ENSG00000101916
Guide to Pharmacology 1758 (TLR8)
PharmGKB PA38009
Reactome REACT_6900 (Signaling in Immune system.)
UniProt B3Y654 Q495P4 Q6UXL6 Q9NR97 Q9NYG9

Target Cross References - Domain

InterPro IPR000157 (Toll-Interleukin_rcpt.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
Pfam PF00560 (LRR_1)
PF01582 (TIR)
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