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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5805
Preferred Name Toll-like receptor 8
Synonyms CD_antigen=CD288 | TLR8 | Toll-like receptor 8
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor > toll-like and il-1 receptors

Target Components

Component Description Relationship Accession
Toll-like receptor 8 SINGLE PROTEIN Q9NR97

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000101916
Ensembl ENSG00000101916
GO Cellular Component GO:0000139 (Golgi membrane)
GO:0005789 (endoplasmic reticulum membrane)
GO:0005887 (integral component of plasma membrane)
GO:0009897 (external side of plasma membrane)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0036020 (endolysosome membrane)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003723 (RNA binding)
GO:0003725 (double-stranded RNA binding)
GO:0003727 (single-stranded RNA binding)
GO:0004888 (transmembrane signaling receptor activity)
GO:0008144 (drug binding)
GO:0038023 (signaling receptor activity)
GO:0042802 (identical protein binding)
GO Biological Process GO:0001774 (microglial cell activation)
GO:0001932 (regulation of protein phosphorylation)
GO:0002224 (toll-like receptor signaling pathway)
GO:0002376 (immune system process)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006954 (inflammatory response)
GO:0007165 (signal transduction)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0009615 (response to virus)
GO:0016064 (immunoglobulin mediated immune response)
GO:0034158 (toll-like receptor 8 signaling pathway)
GO:0034162 (toll-like receptor 9 signaling pathway)
GO:0045078 (positive regulation of interferon-gamma biosynthetic process)
GO:0045087 (innate immune response)
GO:0045089 (positive regulation of innate immune response)
GO:0045356 (positive regulation of interferon-alpha biosynthetic process)
GO:0045359 (positive regulation of interferon-beta biosynthetic process)
GO:0045416 (positive regulation of interleukin-8 biosynthetic process)
GO:0050707 (regulation of cytokine secretion)
GO:0050718 (positive regulation of interleukin-1 beta secretion)
GO:0051607 (defense response to virus)
GO:0071260 (cellular response to mechanical stimulus)
GO:2000778 (positive regulation of interleukin-6 secretion)
GO:2001183 (negative regulation of interleukin-12 secretion)
Wikipedia TLR8

Target Cross References - Protein

canSAR Q9NR97
Human Protein Atlas ENSG00000101916
Guide to Pharmacology 1758
Open Targets ENSG00000101916
PharmGKB PA38009
Reactome R-HSA-1679131 (Trafficking and processing of endosomal TLR.)
R-HSA-168181 (Toll Like Receptor 7/8 (TLR7/8) Cascade.)
R-HSA-975110 (TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling.)
R-HSA-975138 (TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation.)
R-HSA-975155 (MyD88 dependent cascade initiated on endosome.)
UniProt B3Y654 D1CS70 D1CS76 Q495P4 Q6UXL6 Q9NR97 Q9NYG9

Target Cross References - Domain

InterPro IPR000157 (TIR_dom.)
IPR000483 (Cys-rich_flank_reg_C.)
IPR001611 (Leu-rich_rpt.)
IPR003591 (Leu-rich_rpt_typical-subtyp.)
IPR027175 (TLR8.)
IPR032675 (LRR_dom_sf.)
IPR035897 (Toll_tir_struct_dom_sf.)
Pfam PF01582 (TIR)
PF13855 (LRR_8)

Target Cross References - Structure

PDBe 3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ
CREDO 3W3G 3W3J 3W3K 3W3L 3W3M 3W3N 3WN4 4QBZ 4QC0 4R07 4R08 4R09 4R0A 4R6A 5AWA 5AWB 5AWC 5AWD 5AZ5 5HDH 5WYX 5WYZ