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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5784
Target Type SINGLE PROTEIN
Preferred Name NUAK family SNF1-like kinase 1
Synonyms AMPK-related protein kinase 5 | ARK5 | ARK5 | KIAA0537 | NUAK family SNF1-like kinase 1 | NUAK1 | OMPHK1 | Omphalocele kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase nuak subfamily

Target Components

Component Description Relationship Accession
NUAK family SNF1-like kinase 1 SINGLE PROTEIN O60285

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000074590
Ensembl ENSG00000074590
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0015630 (microtubule cytoskeleton)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0002039 (p53 binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0007155 (cell adhesion)
GO:0016310 (phosphorylation)
GO:0030155 (regulation of cell adhesion)
GO:0035507 (regulation of myosin-light-chain-phosphatase activity)
GO:0035556 (intracellular signal transduction)
GO:0042127 (regulation of cell proliferation)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:2000772 (regulation of cellular senescence)
Wikipedia NUAK1

Target Cross References - Protein

canSAR O60285
Human Protein Atlas ENSG00000074590
IntAct O60285
Guide to Pharmacology 2129
Open Targets ENSG00000074590
PharmGKB PA142671242
Pharos O60285 (Tchem)
Reactome R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
UniProt A7MD39 O60285 Q96KA8

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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