ChEMBL logo


ChEMBL Statistics
  Loading Statistics...

Target Report Card

Target Name and Classification

Target ID CHEMBL5780
Preferred Name Sodium/nucleoside cotransporter 2
Synonyms CNT 2 | CNT2 | Concentrative nucleoside transporter 2 | Na(+)/nucleoside cotransporter 2 | SLC28A2 | SPNT | Sodium-coupled nucleoside transporter 2 | Sodium/nucleoside cotransporter 2 | Sodium/purine nucleoside co-transporter | Solute carrier family 28 member 2 | hCNT2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > electrochemical transporter > slc superfamily of solute carriers > slc28 and slc29 families of nucleoside transporters > slc28 na+-coupled nucleoside transport family

Target Components

Component Description Relationship Accession
Sodium/nucleoside cotransporter 2 SINGLE PROTEIN O43868

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000137860
Ensembl ENSG00000137860
GO Cellular Component GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0005337 (nucleoside transmembrane transporter activity)
GO:0005415 (nucleoside:sodium symporter activity)
GO:0015211 (purine nucleoside transmembrane transporter activity)
GO Biological Process GO:0006139 (nucleobase-containing compound metabolic process)
GO:0006810 (transport)
GO:0015860 (purine nucleoside transmembrane transport)
GO:1901642 (nucleoside transmembrane transport)
Wikipedia Concentrative_nucleoside_transporter_2

Target Cross References - Protein

canSAR O43868
Human Protein Atlas ENSG00000137860
IntAct O43868
Guide to Pharmacology 1115
Open Targets ENSG00000137860
PharmGKB PA386
Reactome R-HSA-83936 (Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane.)
UniProt A8K7F9 O43239 O43868 Q52LZ0

Target Cross References - Domain

InterPro IPR002668 (CNT_N_dom.)
IPR008276 (C_nuclsd_transpt.)
IPR011642 (Gate_dom.)
IPR011657 (CNT_C_dom.)
IPR018270 (C_nuclsd_transpt_met_bac.)
IPR030212 (CNT1/CNT2.)
Pfam PF01773 (Nucleos_tra2_N)
PF07662 (Nucleos_tra2_C)
PF07670 (Gate)