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Target Report Card

Target Name and Classification

Target ID CHEMBL5779
Preferred Name Linker for activation of T-cells family member 1
Synonyms 36 kDa phospho-tyrosine adapter protein | LAT | Linker for activation of T-cells family member 1 | p36-38 | pp36
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Linker for activation of T-cells family member 1 SINGLE PROTEIN O43561

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000213658
Ensembl ENSG00000213658
GO Cellular Component GO:0001772 (immunological synapse)
GO:0005886 (plasma membrane)
GO:0005911 (cell-cell junction)
GO:0008180 (COP9 signalosome)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0042629 (mast cell granule)
GO:0045121 (membrane raft)
GO Molecular Function GO:0005070 (SH3/SH2 adaptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0019901 (protein kinase binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0002250 (adaptive immune response)
GO:0002260 (lymphocyte homeostasis)
GO:0002376 (immune system process)
GO:0006954 (inflammatory response)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007229 (integrin-mediated signaling pathway)
GO:0007265 (Ras protein signal transduction)
GO:0009967 (positive regulation of signal transduction)
GO:0010467 (gene expression)
GO:0019722 (calcium-mediated signaling)
GO:0030168 (platelet activation)
GO:0035556 (intracellular signal transduction)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0042110 (T cell activation)
GO:0043303 (mast cell degranulation)
GO:0043547 (positive regulation of GTPase activity)
GO:0045860 (positive regulation of protein kinase activity)
GO:0048872 (homeostasis of number of cells)
GO:0050852 (T cell receptor signaling pathway)
GO:0050863 (regulation of T cell activation)
Wikipedia Linker_of_activated_T_cells

Target Cross References - Protein

canSAR O43561
Human Protein Atlas ENSG00000213658
IntAct O43561
Open Targets ENSG00000213658
PharmGKB PA38728
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-202433 (Generation of second messenger molecules.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2454202 (Fc epsilon receptor (FCERI) signaling.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
UniProt B7WPI0 C7C5T6 G5E9K3 O43561 O43919

Target Cross References - Domain

InterPro IPR008359 (Linker_for_activat_Tcells_prot.)
Pfam PF15234 (LAT)