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Target Report Card

Target Name and Classification

Target ID CHEMBL5778
Preferred Name Forkhead box protein O3
Synonyms AF6q21 protein | FKHRL1 | FOXO3 | FOXO3A | Forkhead box protein O3 | Forkhead in rhabdomyosarcoma-like 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Forkhead box protein O3 SINGLE PROTEIN O43524

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000118689
Ensembl ENSG00000118689
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0016020 (membrane)
GO Molecular Function GO:0001047 (core promoter binding)
GO:0001221 (transcription cofactor binding)
GO:0001227 (transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0001228 (transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0019901 (protein kinase binding)
GO:0031490 (chromatin DNA binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001542 (ovulation from ovarian follicle)
GO:0001544 (initiation of primordial ovarian follicle growth)
GO:0001547 (antral ovarian follicle growth)
GO:0001556 (oocyte maturation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006357 (regulation of transcription from RNA polymerase II promoter)
GO:0006366 (transcription from RNA polymerase II promoter)
GO:0006417 (regulation of translation)
GO:0006915 (apoptotic process)
GO:0030330 (DNA damage response, signal transduction by p53 class mediator)
GO:0033209 (tumor necrosis factor-mediated signaling pathway)
GO:0034599 (cellular response to oxidative stress)
GO:0042593 (glucose homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0090090 (negative regulation of canonical Wnt signaling pathway)
GO:0097150 (neuronal stem cell population maintenance)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:2000177 (regulation of neural precursor cell proliferation)
GO:2000377 (regulation of reactive oxygen species metabolic process)
Wikipedia FOXO3

Target Cross References - Protein

canSAR O43524
Human Protein Atlas ENSG00000118689
IntAct O43524
Open Targets ENSG00000118689
PharmGKB PA28239
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-198693 (AKT phosphorylates targets in the nucleus.)
R-HSA-5674400 (Constitutive Signaling by AKT1 E17K in Cancer.)
R-HSA-5687128 (MAPK6/MAPK4 signaling.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
UniProt B4DVZ6 E1P5E6 O15171 O43524 Q5T2I7 Q9BZ04

Target Cross References - Domain

InterPro IPR001766 (Fork_head_dom.)
IPR011991 (WHTH_DNA-bd_dom.)
IPR030456 (TF_fork_head_CS_2.)
IPR032067 (FOXO-TAD.)
IPR032068 (FOXO_KIX-bd.)
Pfam PF00250 (Forkhead)
PF16675 (FOXO_KIX_bdg)
PF16676 (FOXO-TAD)

Target Cross References - Structure