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Target Report Card

Target Name and Classification

Target ID CHEMBL5777
Preferred Name Bcl-2-like protein 11
Synonyms BCL2L11 | BIM | Bcl-2-like protein 11 | Bcl2-L-11 | Bcl2-interacting mediator of cell death
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Bcl-2-like protein 11 SINGLE PROTEIN O43521

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883287 Bcl-xL/Bcl-2-like protein 11 PROTEIN-PROTEIN INTERACTION
CHEMBL3885524 Bcl-2-like protein 11/Bcl-2-related protein A1 PROTEIN COMPLEX
CHEMBL3430887 Induced myeloid leukemia cell differentiation protein Mcl-1/Bcl-2-like protein 11 PROTEIN-PROTEIN INTERACTION

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000153094
Ensembl ENSG00000153094
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0005829 (cytosol)
GO:0005868 (cytoplasmic dynein complex)
GO:0005874 (microtubule)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0019898 (extrinsic component of membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0097136 (Bcl-2 family protein complex)
GO:0097140 (BIM-BCL-xl complex)
GO:0097141 (BIM-BCL-2 complex)
GO Molecular Function GO:0005515 (protein binding)
GO:0008017 (microtubule binding)
GO:0019901 (protein kinase binding)
GO:0046982 (protein heterodimerization activity)
GO:0070840 (dynein complex binding)
GO Biological Process GO:0001701 (in utero embryonic development)
GO:0001776 (leukocyte homeostasis)
GO:0001782 (B cell homeostasis)
GO:0001783 (B cell apoptotic process)
GO:0001822 (kidney development)
GO:0001844 (protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:0002260 (lymphocyte homeostasis)
GO:0002262 (myeloid cell homeostasis)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0007127 (meiosis I)
GO:0007160 (cell-matrix adhesion)
GO:0007283 (spermatogenesis)
GO:0007420 (brain development)
GO:0008584 (male gonad development)
GO:0008630 (intrinsic apoptotic signaling pathway in response to DNA damage)
GO:0009791 (post-embryonic development)
GO:0010942 (positive regulation of cell death)
GO:0030879 (mammary gland development)
GO:0032464 (positive regulation of protein homooligomerization)
GO:0034976 (response to endoplasmic reticulum stress)
GO:0035148 (tube formation)
GO:0042475 (odontogenesis of dentin-containing tooth)
GO:0042981 (regulation of apoptotic process)
GO:0043029 (T cell homeostasis)
GO:0043065 (positive regulation of apoptotic process)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0043583 (ear development)
GO:0045787 (positive regulation of cell cycle)
GO:0046620 (regulation of organ growth)
GO:0048066 (developmental pigmentation)
GO:0048070 (regulation of developmental pigmentation)
GO:0048536 (spleen development)
GO:0048538 (thymus development)
GO:0048563 (post-embryonic organ morphogenesis)
GO:0060139 (positive regulation of apoptotic process by virus)
GO:0060154 (cellular process regulating host cell cycle in response to virus)
GO:0070242 (thymocyte apoptotic process)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0090200 (positive regulation of release of cytochrome c from mitochondria)
GO:0097192 (extrinsic apoptotic signaling pathway in absence of ligand)
GO:1900740 (positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway)
GO:1902110 (positive regulation of mitochondrial membrane permeability involved in apoptotic process)
GO:1902237 (positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway)
GO:1902263 (apoptotic process involved in embryonic digit morphogenesis)
GO:1903896 (positive regulation of IRE1-mediated unfolded protein response)
GO:2000271 (positive regulation of fibroblast apoptotic process)
GO:2001244 (positive regulation of intrinsic apoptotic signaling pathway)
Wikipedia BCL2L11

Target Cross References - Protein

canSAR O43521
Human Protein Atlas ENSG00000153094
IntAct O43521
Open Targets ENSG00000153094
PharmGKB PA25305
Reactome R-HSA-111446 (Activation of BIM and translocation to mitochondria.)
R-HSA-111453 (BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.)
R-HSA-193648 (NRAGE signals death through JNK.)
R-HSA-6802952 (Signaling by BRAF and RAF fusions.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
R-HSA-8952158 (RUNX3 regulates BCL2L11 (BIM) transcription.)
UniProt A8K2W2 O43521 O43522 Q0MSE7 Q0MSE8 Q0MSE9 Q53R28 Q6JTU6 Q6T851 Q6TE14 Q6TE15 Q6TE16 Q6V402 Q8WYL6 Q8WYL7 Q8WYL8 Q8WYL9 Q8WYM0 Q8WYM1

Target Cross References - Domain

InterPro IPR014771 (Apoptosis_Bim_N.)
IPR015040 (Bcl-x_interacting_BH3_dom.)
IPR017288 (Bcl-2-like_11.)
Pfam PF06773 (Bim_N)
PF08945 (Bclx_interact)

Target Cross References - Structure

PDBe 2NL9 2V6Q 2VM6 2WH6 2YQ6 2YQ7 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4A1U 4A1W 4B4S 4D2M 4QVF 4UF3 4YJ4 4ZIE 4ZIF 4ZIH 5AGW More...
CREDO 2NL9 2V6Q 2VM6 2WH6 2YQ6 2YQ7 3D7V 3FDL 3IO8 3IO9 3KJ0 3KJ1 3KJ2 4A1U 4A1W 4B4S 4D2M 4QVF 4UF3 4YJ4 4ZIE 4ZIF 4ZIH 5AGW More...