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Target Report Card

Target Name and Classification

Target ID CHEMBL5776
Preferred Name Mitogen-activated protein kinase kinase kinase 7
Synonyms MAP3K7 | Mitogen-activated protein kinase kinase kinase 7 | TAK1 | TGF-beta-activated kinase 1 | Transforming growth factor-beta-activated kinase 1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase mlk family > tkl protein kinase tak1 subfamily

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase kinase kinase 7 SINGLE PROTEIN O43318

Target Relations

ChEMBL ID Pref Name Target Type

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000135341
Ensembl ENSG00000135341
GO Cellular Component GO:0005634 (nucleus)
GO:0005671 (Ada2/Gcn5/Ada3 transcription activator complex)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008385 (IkappaB kinase complex)
GO:0010008 (endosome membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0000287 (magnesium ion binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004709 (MAP kinase kinase kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0002726 (positive regulation of T cell cytokine production)
GO:0002755 (MyD88-dependent toll-like receptor signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007165 (signal transduction)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0007223 (Wnt signaling pathway, calcium modulating pathway)
GO:0007249 (I-kappaB kinase/NF-kappaB signaling)
GO:0007250 (activation of NF-kappaB-inducing kinase activity)
GO:0007252 (I-kappaB phosphorylation)
GO:0007254 (JNK cascade)
GO:0016310 (phosphorylation)
GO:0032743 (positive regulation of interleukin-2 production)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043507 (positive regulation of JUN kinase activity)
GO:0043966 (histone H3 acetylation)
GO:0050852 (T cell receptor signaling pathway)
GO:0050870 (positive regulation of T cell activation)
GO:0051092 (positive regulation of NF-kappaB transcription factor activity)
GO:0051403 (stress-activated MAPK cascade)
GO:0070423 (nucleotide-binding oligomerization domain containing signaling pathway)
Wikipedia MAP3K7

Target Cross References - Protein

canSAR O43318
Human Protein Atlas ENSG00000135341
IntAct O43318
Guide to Pharmacology 2082
Open Targets ENSG00000135341
PharmGKB PA30603
Pharos O43318 (Tchem)
Reactome R-HSA-1169091 (Activation of NF-kappaB in B cells.)
R-HSA-168638 (NOD1/2 Signaling Pathway.)
R-HSA-202424 (Downstream TCR signaling.)
R-HSA-2871837 (FCERI mediated NF-kB activation.)
R-HSA-4086398 (Ca2+ pathway.)
R-HSA-445989 (TAK1 activates NFkB by phosphorylation and activation of IKKs complex.)
R-HSA-446652 (Interleukin-1 signaling.)
R-HSA-450302 (activated TAK1 mediates p38 MAPK activation.)
R-HSA-450321 (JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1.)
R-HSA-5357956 (TNFR1-induced NFkappaB signaling pathway.)
R-HSA-5607764 (CLEC7A (Dectin-1) signaling.)
R-HSA-937042 (IRAK2 mediated activation of TAK1 complex.)
R-HSA-937072 (TRAF6 mediated induction of TAK1 complex.)
R-HSA-975163 (IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation.)
UniProt B2RE27 E1P523 O43317 O43318 O43319 Q5TDN2 Q5TDN3 Q5TDT7 Q9NTR3 Q9NZ70

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017421 (MAPKKK7.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF07714 (Pkinase_Tyr)

Target Cross References - Structure

PDBe 2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91
CREDO 2EVA 2YIY 4GS6 4L3P 4L52 4L53 4O91