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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5759
Target Type SINGLE PROTEIN
Preferred Name Mitogen-activated protein kinase 4
Synonyms ERK-4 | ERK4 | Extracellular signal-regulated kinase 4 | MAP kinase 4 | MAP kinase isoform p63 | MAPK 4 | MAPK4 | Mitogen-activated protein kinase 4 | PRKM4 | p63-MAPK
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase mapk family > cmgc protein kinase erk3

Target Components

Component Description Relationship Accession
Mitogen-activated protein kinase 4 SINGLE PROTEIN P31152

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141639
Ensembl ENSG00000141639
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004707 (MAP kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0019901 (protein kinase binding)
GO:0042803 (protein homodimerization activity)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0006468 (protein phosphorylation)
GO:0007049 (cell cycle)
GO:0016310 (phosphorylation)
Wikipedia MAPK4

Target Cross References - Protein

canSAR P31152
Human Protein Atlas ENSG00000141639
IntAct P31152
Guide to Pharmacology 2091
Open Targets ENSG00000141639
PharmGKB PA30623
Pharos P31152 (Tbio)
Reactome R-HSA-5687128 (MAPK6/MAPK4 signaling.)
UniProt A1A4C4 P31152 Q0VG04

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008350 (MAPK_ERK3/4.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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