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Target Report Card

Target Name and Classification

Target ID CHEMBL5758
Target Type SINGLE PROTEIN
Preferred Name Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Synonyms Flavoprotein subunit of complex II | Fp | SDH2 | SDHA | SDHF | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial SINGLE PROTEIN P31040

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000073578
Ensembl ENSG00000073578
GO Cellular Component GO:0005739 (mitochondrion)
GO:0005743 (mitochondrial inner membrane)
GO:0005749 (mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone))
GO:0016020 (membrane)
GO:0043209 (myelin sheath)
GO Molecular Function GO:0000104 (succinate dehydrogenase activity)
GO:0005515 (protein binding)
GO:0008177 (succinate dehydrogenase (ubiquinone) activity)
GO:0016491 (oxidoreductase activity)
GO:0016627 (oxidoreductase activity, acting on the CH-CH group of donors)
GO:0050660 (flavin adenine dinucleotide binding)
GO Biological Process GO:0006099 (tricarboxylic acid cycle)
GO:0006105 (succinate metabolic process)
GO:0007399 (nervous system development)
GO:0022900 (electron transport chain)
GO:0022904 (respiratory electron transport chain)
GO:0055114 (oxidation-reduction process)
Wikipedia SDHA

Target Cross References - Protein

canSAR P31040
CGD Paragangliomas 5; Gastrointestinal stromal tumors; Cardiomyopathy, dilated, 1GG; Leigh syndrome/Mitochondrial respiratory chain complex II deficiency
Human Protein Atlas ENSG00000073578
IntAct P31040
Open Targets ENSG00000073578
PharmGKB PA35605
Reactome R-HSA-611105 (Respiratory electron transport.)
R-HSA-71403 (Citric acid cycle (TCA cycle).)
UniProt A8K5J6 B4DJ60 E9PBJ5 P31040 Q16395 Q59GW8 Q8IW48 Q9UMY5

Target Cross References - Domain

InterPro IPR003952 (FRD_SDH_FAD_BS.)
IPR003953 (FAD-binding_2.)
IPR011281 (Succ_DH_flav_su_fwd.)
IPR014006 (Succ_Dhase_FrdA_Gneg.)
IPR015939 (Fum_Rdtase/Succ_DH_flav-like_C.)
IPR023753 (FAD/NAD-binding_dom.)
IPR027477 (Succ_DH/fumarate_Rdtase_cat.)
IPR030664 (SdhA/FrdA/AprA.)
Pfam PF00890 (FAD_binding_2)
PF02910 (Succ_DH_flav_C)
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