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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5750
Target Type SINGLE PROTEIN
Preferred Name Histone acetyltransferase KAT5
Synonyms 60 kDa Tat-interactive protein | HIV-1 Tat interactive protein | HTATIP | Histone acetyltransferase HTATIP | Histone acetyltransferase KAT5 | KAT5 | Lysine acetyltransferase 5 | TIP60 | Tip60 | cPLA(2)-interacting protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > chromodomain
  • epigenetic regulator > writer > histone acetyltransferase > myst family

Target Components

Component Description Relationship Accession
Histone acetyltransferase KAT5 SINGLE PROTEIN Q92993

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172977
Ensembl ENSG00000172977
GO Cellular Component GO:0005730 (nucleolus)
GO:0032777 (Piccolo NuA4 histone acetyltransferase complex)
GO:0035267 (NuA4 histone acetyltransferase complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0016564 (transcription repressor activity)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006302 (double-strand break repair)
GO:0006351 (transcription, DNA-dependent)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0030521 (androgen receptor signaling pathway)
GO:0032703 (negative regulation of interleukin-2 production)
GO:0040008 (regulation of growth)
GO:0044419 (interspecies interaction between organisms)
GO:0045893 (positive regulation of transcription, DNA-dependent)
Wikipedia KAT5

Target Cross References - Protein

canSAR Q92993
Human Protein Atlas ENSG00000172977
IntAct Q92993
PharmGKB PA162392746
UniProt O95624 Q13430 Q17RW5 Q561W3 Q6GSE8 Q92993 Q9BWK7

Target Cross References - Domain

InterPro IPR000953 (Chromo_domain/shadow.)
IPR002717 (MOZ_SAS.)
IPR016181 (Acyl_CoA_acyltransferase.)
IPR016197 (Chromodomain-like.)
Pfam PF01853 (MOZ_SAS)

Target Cross References - Structure

PDBe 2OU2
CREDO 2OU2
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