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Target Report Card

Target Name and Classification

Target ID CHEMBL5750
Target Type SINGLE PROTEIN
Preferred Name Histone acetyltransferase KAT5
Synonyms 60 kDa Tat-interactive protein | HIV-1 Tat interactive protein | HTATIP | Histone acetyltransferase HTATIP | Histone acetyltransferase KAT5 | KAT5 | Lysine acetyltransferase 5 | TIP60 | Tip60 | cPLA(2)-interacting protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > reader > methyl-lysine/arginine binding protein > chromodomain
  • epigenetic regulator > writer > histone acetyltransferase > myst family

Target Components

Component Description Relationship Accession
Histone acetyltransferase KAT5 SINGLE PROTEIN Q92993

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000172977
Ensembl ENSG00000172977
GO Cellular Component GO:0000812 (Swr1 complex)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0032777 (Piccolo NuA4 histone acetyltransferase complex)
GO:0035267 (NuA4 histone acetyltransferase complex)
GO:0048471 (perinuclear region of cytoplasm)
GO Molecular Function GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0005515 (protein binding)
GO:0016407 (acetyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0016747 (transferase activity, transferring acyl groups other than amino-acyl groups)
GO:0046872 (metal ion binding)
GO:0050681 (androgen receptor binding)
GO:0070491 (repressing transcription factor binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0000729 (DNA double-strand break processing)
GO:0000731 (DNA synthesis involved in DNA repair)
GO:0000732 (strand displacement)
GO:0006260 (DNA replication)
GO:0006302 (double-strand break repair)
GO:0006303 (double-strand break repair via nonhomologous end joining)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006978 (DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator)
GO:0010212 (response to ionizing radiation)
GO:0016032 (viral process)
GO:0016568 (chromatin modification)
GO:0016573 (histone acetylation)
GO:0030521 (androgen receptor signaling pathway)
GO:0032703 (negative regulation of interleukin-2 production)
GO:0040008 (regulation of growth)
GO:0043161 (proteasome-mediated ubiquitin-dependent protein catabolic process)
GO:0045892 (negative regulation of transcription, DNA-templated)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0071392 (cellular response to estradiol stimulus)
GO:1901796 (regulation of signal transduction by p53 class mediator)
GO:1901985 (positive regulation of protein acetylation)
GO:1904837 (beta-catenin-TCF complex assembly)
Wikipedia KAT5

Target Cross References - Protein

canSAR Q92993
Human Protein Atlas ENSG00000172977
IntAct Q92993
Guide to Pharmacology 2664
Open Targets ENSG00000172977
PharmGKB PA162392746
Reactome R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-2559586 (DNA Damage/Telomere Stress Induced Senescence.)
R-HSA-3214847 (HATs acetylate histones.)
R-HSA-5685938 (HDR through Single Strand Annealing (SSA).)
R-HSA-5685942 (HDR through Homologous Recombination (HRR).)
R-HSA-5693548 (Sensing of DNA Double Strand Breaks.)
R-HSA-5693554 (Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA).)
R-HSA-5693565 (Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks.)
R-HSA-5693568 (Resolution of D-loop Structures through Holliday Junction Intermediates.)
R-HSA-5693571 (Nonhomologous End-Joining (NHEJ).)
R-HSA-5693579 (Homologous DNA Pairing and Strand Exchange.)
R-HSA-5693607 (Processing of DNA double-strand break ends.)
R-HSA-5693616 (Presynaptic phase of homologous DNA pairing and strand exchange.)
R-HSA-6804756 (Regulation of TP53 Activity through Phosphorylation.)
R-HSA-69473 (G2/M DNA damage checkpoint.)
UniProt B4E3C7 C9JL99 O95624 Q13430 Q17RW5 Q561W3 Q6GSE8 Q92993 Q9BWK7

Target Cross References - Domain

InterPro IPR000953 (Chromo/chromo_shadow_dom.)
IPR002717 (HAT_MYST-type.)
IPR016181 (Acyl_CoA_acyltransferase.)
IPR016197 (Chromodomain-like.)
IPR025995 (Tudor-knot.)
Pfam PF01853 (MOZ_SAS)
PF11717 (Tudor-knot)

Target Cross References - Structure

PDBe 2OU2 4QQG
CREDO 2OU2 4QQG
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