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Target Report Card

Target Name and Classification

Target ID CHEMBL5748
Preferred Name Canalicular multispecific organic anion transporter 1
Synonyms ABCC2 | ATP-binding cassette sub-family C member 2 | CMOAT | CMOAT1 | CMRP | Canalicular multidrug resistance protein | Canalicular multispecific organic anion transporter 1 | MRP2 | Multidrug resistance-associated protein 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
Canalicular multispecific organic anion transporter 1 SINGLE PROTEIN Q92887

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000023839
Ensembl ENSG00000023839
GO Cellular Component GO:0005887 (integral to plasma membrane)
GO:0016324 (apical plasma membrane)
GO Molecular Function GO:0005524 (ATP binding)
GO:0008514 (organic anion transmembrane transporter activity)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
Wikipedia Multidrug_resistance-associated_protein_2

Target Cross References - Protein

CGD Dubin-Johnson syndrome
Human Protein Atlas ENSG00000023839
Guide to Pharmacology 780 (ABCC2)
PharmGKB PA116
UniProt B2RMT8 Q14022 Q5T2B1 Q92500 Q92798 Q92887 Q99663 Q9UMS2

Target Cross References - Domain

InterPro IPR001140 (ABC_transptr_TM_dom.)
IPR003439 (ABC_transporter-like.)
IPR003593 (ATPase_AAA+_core.)
IPR005292 (Multidrug-R_assoc.)
IPR011527 (ABC_transptrTM_dom_typ1.)
IPR017871 (ABC_transporter_CS.)
IPR017940 (ABC_transporter_type1.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)