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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5748
Target Type SINGLE PROTEIN
Preferred Name Canalicular multispecific organic anion transporter 1
Synonyms Object
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > atp-binding cassette > abcc subfamily

Target Components

Component Description Relationship Accession
Canalicular multispecific organic anion transporter 1 SINGLE PROTEIN Q92887

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000023839
Ensembl ENSG00000023839
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO:0009986 (cell surface)
GO:0016324 (apical plasma membrane)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0008514 (organic anion transmembrane transporter activity)
GO:0005524 (ATP binding)
GO:0042626 (ATPase activity, coupled to transmembrane movement of substances)
GO Biological Process GO:0009408 (response to heat)
GO:0055085 (transmembrane transport)
GO:0070327 (thyroid hormone transport)
GO:0030644 (cellular chloride ion homeostasis)
GO:0043627 (response to estrogen)
GO:0046685 (response to arsenic-containing substance)
GO:0006810 (transport)
GO:0006855 (drug transmembrane transport)
GO:0006979 (response to oxidative stress)
GO:0015732 (prostaglandin transport)
GO:0031427 (response to methotrexate)
Wikipedia Multidrug_resistance-associated_protein_2

Target Cross References - Protein

CGD Dubin-Johnson syndrome
Human Protein Atlas ENSG00000023839
IntAct Q92887
Guide to Pharmacology 780 (ABCC2)
PharmGKB PA116
UniProt Q99663 Q92887 Q92500 B2RMT8 Q5T2B1 Q92798 Q14022 Q9UMS2

Target Cross References - Domain

InterPro IPR003439 (ABC_transporter-like.)
IPR005292 (Multidrug-R_assoc.)
IPR017871 (ABC_transporter_CS.)
IPR011527 (ABC1_TM_dom.)
IPR027417 (P-loop_NTPase.)
IPR003593 (AAA+_ATPase.)
IPR030247 (ABCC2.)
Pfam PF00005 (ABC_tran)
PF00664 (ABC_membrane)
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