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Target Report Card

Target Name and Classification

Target ID CHEMBL5747
Preferred Name CREB-binding protein
Synonyms CBP | CREB-binding protein | CREBBP
Organism Homo sapiens
Species Group No
Protein Target Classification
  • epigenetic regulator > writer > histone acetyltransferase > p300/cbp family
  • epigenetic regulator > reader > bromodomain

Target Components

Component Description Relationship Accession
CREB-binding protein SINGLE PROTEIN Q92793

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3883300 CREB-binding protein/Histone acetyltransferase p300 PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000005339
Ensembl ENSG00000005339
GO Cellular Component GO:0000123 (histone acetyltransferase complex)
GO:0000790 (nuclear chromatin)
GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0016604 (nuclear body)
GO Molecular Function GO:0000987 (core promoter proximal region sequence-specific DNA binding)
GO:0001078 (transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding)
GO:0001085 (RNA polymerase II transcription factor binding)
GO:0001102 (RNA polymerase II activating transcription factor binding)
GO:0001105 (RNA polymerase II transcription coactivator activity)
GO:0001191 (transcriptional repressor activity, RNA polymerase II transcription factor binding)
GO:0002039 (p53 binding)
GO:0003682 (chromatin binding)
GO:0003684 (damaged DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003712 (transcription cofactor activity)
GO:0003713 (transcription coactivator activity)
GO:0004402 (histone acetyltransferase activity)
GO:0004871 (signal transducer activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0008270 (zinc ion binding)
GO:0016407 (acetyltransferase activity)
GO:0016740 (transferase activity)
GO:0016746 (transferase activity, transferring acyl groups)
GO:0034212 (peptide N-acetyltransferase activity)
GO:0043426 (MRF binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0001666 (response to hypoxia)
GO:0002223 (stimulatory C-type lectin receptor signaling pathway)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006473 (protein acetylation)
GO:0007165 (signal transduction)
GO:0007219 (Notch signaling pathway)
GO:0007221 (positive regulation of transcription of Notch receptor target)
GO:0008589 (regulation of smoothened signaling pathway)
GO:0016032 (viral process)
GO:0016573 (histone acetylation)
GO:0018076 (N-terminal peptidyl-lysine acetylation)
GO:0019216 (regulation of lipid metabolic process)
GO:0031648 (protein destabilization)
GO:0032481 (positive regulation of type I interferon production)
GO:0034644 (cellular response to UV)
GO:0042592 (homeostatic process)
GO:0042733 (embryonic digit morphogenesis)
GO:0042981 (regulation of apoptotic process)
GO:0045637 (regulation of myeloid cell differentiation)
GO:0045747 (positive regulation of Notch signaling pathway)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048511 (rhythmic process)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
GO:0065003 (protein-containing complex assembly)
GO:1900034 (regulation of cellular response to heat)
GO:1904837 (beta-catenin-TCF complex assembly)
Wikipedia CREB-binding_protein

Target Cross References - Protein

canSAR Q92793
CGD Rubinstein-Taybi syndrome
Human Protein Atlas ENSG00000005339
IntAct Q92793
Guide to Pharmacology 2734
Open Targets ENSG00000005339
PharmGKB PA26866
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1368082 (RORA activates gene expression.)
R-HSA-1368108 (BMAL1:CLOCK,NPAS2 activates circadian gene expression.)
R-HSA-1912408 (Pre-NOTCH Transcription and Translation.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-201722 (Formation of the beta-catenin:TCF transactivating complex.)
R-HSA-2032785 (YAP1- and WWTR1 (TAZ)-stimulated gene expression.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-2151201 (Transcriptional activation of mitochondrial biogenesis.)
R-HSA-2426168 (Activation of gene expression by SREBF (SREBP).)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-3134973 (LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production.)
R-HSA-3214847 (HATs acetylate histones.)
R-HSA-3371568 (Attenuation phase.)
R-HSA-350054 (Notch-HLH transcription pathway.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
R-HSA-400206 (Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha).)
R-HSA-400253 (Circadian Clock.)
R-HSA-5617472 (Activation of anterior HOX genes in hindbrain development during early embryogenesis.)
R-HSA-5621575 (CD209 (DC-SIGN) signaling.)
R-HSA-6803204 (TP53 Regulates Transcription of Genes Involved in Cytochrome C Release.)
R-HSA-8866907 (Activation of the TFAP2 (AP-2) family of transcription factors.)
R-HSA-8939246 (RUNX1 regulates transcription of genes involved in differentiation of myeloid cells.)
R-HSA-8941856 (RUNX3 regulates NOTCH signaling.)
R-HSA-8951671 (RUNX3 regulates YAP1-mediated transcription.)
R-HSA-9013508 (NOTCH3 Intracellular Domain Regulates Transcription.)
R-HSA-918233 (TRAF3-dependent IRF activation pathway.)
R-HSA-933541 (TRAF6 mediated IRF7 activation.)
R-HSA-983231 (Factors involved in megakaryocyte development and platelet production.)
UniProt D3DUC9 O00147 Q16376 Q4LE28 Q92793

Target Cross References - Domain

InterPro IPR000197 (Znf_TAZ.)
IPR000433 (Znf_ZZ.)
IPR001487 (Bromodomain.)
IPR003101 (KIX_dom.)
IPR009110 (Nuc_rcpt_coact.)
IPR010303 (RING_CBP-p300.)
IPR013083 (Znf_RING/FYVE/PHD.)
IPR013178 (Histone_AcTrfase_Rtt109/CBP.)
IPR014744 (Nuc_rcpt_coact_CREBbp.)
IPR018359 (Bromodomain_CS.)
IPR031162 (CBP_P300_HAT.)
IPR035898 (TAZ_dom_sf.)
IPR036427 (Bromodomain-like_sf.)
IPR036529 (KIX_dom_sf.)
IPR037073 (Nuc_rcpt_coact_CREBbp_sf.)
Pfam PF00439 (Bromodomain)
PF00569 (ZZ)
PF02135 (zf-TAZ)
PF02172 (KIX)
PF06001 (DUF902)
PF08214 (HAT_KAT11)
PF09030 (Creb_binding)

Target Cross References - Structure

PDBe 1RDT 1ZOQ 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP More...
CREDO 1RDT 1ZOQ 3DWY 3P1C 3P1D 3P1E 3P1F 3SVH 4A9K 4N3W 4N4F 4NR4 4NR5 4NR6 4NR7 4NYV 4NYW 4NYX 4OUF 4TQN 4TS8 4WHU 4YK0 5CGP More...