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Target Report Card

Target Name and Classification

Target ID CHEMBL5742
Preferred Name Translocator protein
Synonyms BZRP | MBR | Mitochondrial benzodiazepine receptor | PBR | PKBS | Peripheral-type benzodiazepine receptor | TSPO | Translocator protein
Organism Homo sapiens
Species Group No
Protein Target Classification
  • membrane receptor

Target Components

Component Description Relationship Accession
Translocator protein SINGLE PROTEIN P30536

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000100300
Ensembl ENSG00000100300
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005741 (mitochondrial outer membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031965 (nuclear membrane)
GO:0031966 (mitochondrial membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO:0098794 (postsynapse)
GO Molecular Function GO:0005497 (androgen binding)
GO:0005515 (protein binding)
GO:0008503 (benzodiazepine receptor activity)
GO:0015485 (cholesterol binding)
GO:0044325 (ion channel binding)
GO Biological Process GO:0006626 (protein targeting to mitochondrion)
GO:0006694 (steroid biosynthetic process)
GO:0006783 (heme biosynthetic process)
GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0006820 (anion transport)
GO:0006821 (chloride transport)
GO:0006869 (lipid transport)
GO:0006915 (apoptotic process)
GO:0007268 (chemical synaptic transmission)
GO:0007568 (aging)
GO:0008202 (steroid metabolic process)
GO:0008283 (cell proliferation)
GO:0008347 (glial cell migration)
GO:0010042 (response to manganese ion)
GO:0010266 (response to vitamin B1)
GO:0010823 (negative regulation of mitochondrion organization)
GO:0010940 (positive regulation of necrotic cell death)
GO:0014012 (peripheral nervous system axon regeneration)
GO:0030325 (adrenal gland development)
GO:0031397 (negative regulation of protein ubiquitination)
GO:0032374 (regulation of cholesterol transport)
GO:0032570 (response to progesterone)
GO:0032720 (negative regulation of tumor necrosis factor production)
GO:0033574 (response to testosterone)
GO:0042493 (response to drug)
GO:0043065 (positive regulation of apoptotic process)
GO:0045019 (negative regulation of nitric oxide biosynthetic process)
GO:0048265 (response to pain)
GO:0048266 (behavioral response to pain)
GO:0048678 (response to axon injury)
GO:0050810 (regulation of steroid biosynthetic process)
GO:0051901 (positive regulation of mitochondrial depolarization)
GO:0051928 (positive regulation of calcium ion transport)
GO:0060242 (contact inhibition)
GO:0060252 (positive regulation of glial cell proliferation)
GO:0060253 (negative regulation of glial cell proliferation)
GO:0071222 (cellular response to lipopolysaccharide)
GO:0071294 (cellular response to zinc ion)
GO:0071476 (cellular hypotonic response)
GO:0072655 (establishment of protein localization to mitochondrion)
GO:0072656 (maintenance of protein location in mitochondrion)
GO:0099565 (chemical synaptic transmission, postsynaptic)
GO:1903147 (negative regulation of mitophagy)
GO:1903579 (negative regulation of ATP metabolic process)
GO:2000379 (positive regulation of reactive oxygen species metabolic process)
Wikipedia Translocator_protein

Target Cross References - Protein

Human Protein Atlas ENSG00000100300
IntAct P30536
Guide to Pharmacology 2879
Open Targets ENSG00000100300
PharmGKB PA25473
UniProt P30536 Q53Y59 Q6ICF9 Q96TF6

Target Cross References - Domain

InterPro IPR004307 (TspO_MBR.)
IPR030164 (TSPO.)
Pfam PF03073 (TspO_MBR)