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Target Report Card

Target Name and Classification

Target ID CHEMBL5736
Target Type SINGLE PROTEIN
Preferred Name Glucagon
Synonyms GCG | GLP-1 | GLP-1(7-36) | GLP-1(7-37) | GLP-2 | GRPP | Glicentin | Glicentin-related polypeptide | Glucagon | Glucagon-like peptide 1 | Glucagon-like peptide 1(7-36) | Glucagon-like peptide 1(7-37) | Glucagon-like peptide 2 | Incretin hormone | OXM | OXY | Oxyntomodulin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Glucagon SINGLE PROTEIN P01275

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000115263
Ensembl ENSG00000115263
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005737 (cytoplasm)
GO:0005788 (endoplasmic reticulum lumen)
GO:0005886 (plasma membrane)
GO:0034774 (secretory granule lumen)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005179 (hormone activity)
GO:0005515 (protein binding)
GO:0031769 (glucagon receptor binding)
GO:0042802 (identical protein binding)
GO Biological Process GO:0007165 (signal transduction)
GO:0007186 (G-protein coupled receptor signaling pathway)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007631 (feeding behavior)
GO:0008283 (cell proliferation)
GO:0010737 (protein kinase A signaling)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0032092 (positive regulation of protein binding)
GO:0032099 (negative regulation of appetite)
GO:0033138 (positive regulation of peptidyl-serine phosphorylation)
GO:0035774 (positive regulation of insulin secretion involved in cellular response to glucose stimulus)
GO:0035948 (positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter)
GO:0042594 (response to starvation)
GO:0043066 (negative regulation of apoptotic process)
GO:0045860 (positive regulation of protein kinase activity)
GO:0050796 (regulation of insulin secretion)
GO:0051571 (positive regulation of histone H3-K4 methylation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0071377 (cellular response to glucagon stimulus)
GO:0090280 (positive regulation of calcium ion import)
GO:1900118 (negative regulation of execution phase of apoptosis)
GO:2001243 (negative regulation of intrinsic apoptotic signaling pathway)
Wikipedia Glucagon

Target Cross References - Protein

canSAR P01275
Human Protein Atlas ENSG00000115263
IntAct P01275
Open Targets ENSG00000115263
PharmGKB PA28606
Reactome R-HSA-163359 (Glucagon signaling in metabolic regulation.)
R-HSA-381676 (Glucagon-like Peptide-1 (GLP1) regulates insulin secretion.)
R-HSA-381771 (Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1).)
R-HSA-416476 (G alpha (q) signalling events.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-420092 (Glucagon-type ligand receptors.)
R-HSA-422085 (Synthesis, secretion, and deacylation of Ghrelin.)
UniProt A6NN65 P01275 Q53TP6

Target Cross References - Domain

InterPro IPR000532 (Glucagon_GIP_secretin_VIP.)
IPR015550 (Glucagon.)
Pfam PF00123 (Hormone_2)

Target Cross References - Structure

PDBe 1BH0 2G49 3IOL 4ZGM
CREDO 1BH0 2G49 3IOL 4ZGM
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