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Target Report Card

Target Name and Classification

Target ID CHEMBL5734
Target Type SINGLE PROTEIN
Preferred Name Pro-epidermal growth factor
Synonyms EGF | EGF | Epidermal growth factor | Pro-epidermal growth factor | Urogastrone
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Pro-epidermal growth factor SINGLE PROTEIN P01133

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138798
Ensembl ENSG00000138798
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005765 (lysosomal membrane)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0031093 (platelet alpha granule lumen)
GO:0043235 (receptor complex)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0004713 (protein tyrosine kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005509 (calcium ion binding)
GO:0005515 (protein binding)
GO:0008083 (growth factor activity)
GO:0017147 (Wnt-protein binding)
GO:0030297 (transmembrane receptor protein tyrosine kinase activator activity)
GO:0042813 (Wnt-activated receptor activity)
GO:0046934 (phosphatidylinositol-4,5-bisphosphate 3-kinase activity)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000186 (activation of MAPKK activity)
GO:0000187 (activation of MAPK activity)
GO:0001525 (angiogenesis)
GO:0002576 (platelet degranulation)
GO:0006260 (DNA replication)
GO:0007165 (signal transduction)
GO:0007171 (activation of transmembrane receptor protein tyrosine kinase activity)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007262 (STAT protein import into nucleus)
GO:0008284 (positive regulation of cell proliferation)
GO:0010800 (positive regulation of peptidyl-threonine phosphorylation)
GO:0014066 (regulation of phosphatidylinositol 3-kinase signaling)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0021940 (positive regulation of cerebellar granule cell precursor proliferation)
GO:0035413 (positive regulation of catenin import into nucleus)
GO:0038128 (ERBB2 signaling pathway)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0042327 (positive regulation of phosphorylation)
GO:0043388 (positive regulation of DNA binding)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0043547 (positive regulation of GTPase activity)
GO:0044332 (Wnt signaling pathway involved in dorsal/ventral axis specification)
GO:0045741 (positive regulation of epidermal growth factor-activated receptor activity)
GO:0045840 (positive regulation of mitotic nuclear division)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0046854 (phosphatidylinositol phosphorylation)
GO:0048015 (phosphatidylinositol-mediated signaling)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0050730 (regulation of peptidyl-tyrosine phosphorylation)
GO:0050731 (positive regulation of peptidyl-tyrosine phosphorylation)
GO:0051048 (negative regulation of secretion)
GO:0060070 (canonical Wnt signaling pathway)
GO:0060749 (mammary gland alveolus development)
GO:0070371 (ERK1 and ERK2 cascade)
GO:0090279 (regulation of calcium ion import)
GO:0090370 (negative regulation of cholesterol efflux)
GO:1900127 (positive regulation of hyaluronan biosynthetic process)
GO:2000008 (regulation of protein localization to cell surface)
GO:2000060 (positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process)
GO:2000145 (regulation of cell motility)
Wikipedia Epidermal_growth_factor

Target Cross References - Protein

canSAR P01133
CGD Hypomagnesemia 4, renal
Human Protein Atlas ENSG00000138798
IntAct P01133
Open Targets ENSG00000138798
PharmGKB PA27664
Reactome R-HSA-114608 (Platelet degranulation.)
R-HSA-1227986 (Signaling by ERBB2.)
R-HSA-1236382 (Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.)
R-HSA-1236394 (Signaling by ERBB4.)
R-HSA-1250196 (SHC1 events in ERBB2 signaling.)
R-HSA-1251932 (PLCG1 events in ERBB2 signaling.)
R-HSA-1257604 (PIP3 activates AKT signaling.)
R-HSA-177929 (Signaling by EGFR.)
R-HSA-179812 (GRB2 events in EGFR signaling.)
R-HSA-180292 (GAB1 signalosome.)
R-HSA-180336 (SHC1 events in EGFR signaling.)
R-HSA-182971 (EGFR downregulation.)
R-HSA-1963640 (GRB2 events in ERBB2 signaling.)
R-HSA-1963642 (PI3K events in ERBB2 signaling.)
R-HSA-212718 (EGFR interacts with phospholipase C-gamma.)
R-HSA-2219530 (Constitutive Signaling by Aberrant PI3K in Cancer.)
R-HSA-5637810 (Constitutive Signaling by EGFRvIII.)
R-HSA-5638303 (Inhibition of Signaling by Overexpressed EGFR.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-6785631 (ERBB2 Regulates Cell Motility.)
R-HSA-6811558 (PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.)
R-HSA-8847993 (ERBB2 Activates PTK6 Signaling.)
R-HSA-8856825 (Cargo recognition for clathrin-mediated endocytosis.)
R-HSA-8856828 (Clathrin-mediated endocytosis.)
R-HSA-8863795 (Downregulation of ERBB2 signaling.)
UniProt B4DRK7 E7EVD2 E9PBF0 P01133 Q52LZ6

Target Cross References - Domain

InterPro IPR000033 (LDLR_classB_rpt.)
IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000742 (EGF-like_dom.)
IPR001881 (EGF-like_Ca-bd_dom.)
IPR009030 (Growth_fac_rcpt_.)
IPR011042 (6-blade_b-propeller_TolB-like.)
IPR013032 (EGF-like_CS.)
IPR016317 (Pro-epidermal_GF.)
IPR018097 (EGF_Ca-bd_CS.)
IPR023413 (GFP-like.)
Pfam PF00008 (EGF)
PF00058 (Ldl_recept_b)
PF07645 (EGF_CA)

Target Cross References - Structure

PDBe 1IVO 1JL9 1NQL 3NJP
CREDO 1IVO 1JL9 1NQL 3NJP
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