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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5734
Target Type SINGLE PROTEIN
Preferred Name Pro-epidermal growth factor
Synonyms EGF | EGF | Epidermal growth factor | Pro-epidermal growth factor | Urogastrone
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Pro-epidermal growth factor SINGLE PROTEIN P01133

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138798
Ensembl ENSG00000138798
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016021 (integral to membrane)
GO:0031093 (platelet alpha granule lumen)
GO Molecular Function GO:0005154 (epidermal growth factor receptor binding)
GO:0005509 (calcium ion binding)
GO:0008083 (growth factor activity)
GO:0030297 (transmembrane receptor protein tyrosine kinase activator activity)
GO Biological Process GO:0001525 (angiogenesis)
GO:0002576 (platelet degranulation)
GO:0006260 (DNA replication)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0030168 (platelet activation)
GO:0035413 (positive regulation of catenin import into nucleus)
GO:0042059 (negative regulation of epidermal growth factor receptor signaling pathway)
GO:0043406 (positive regulation of MAP kinase activity)
GO:0045741 (positive regulation of epidermal growth factor receptor activity)
GO:0045840 (positive regulation of mitosis)
GO:0051048 (negative regulation of secretion)
GO:0090279 (regulation of calcium ion import)
GO:2000008 (regulation of protein localization at cell surface)
Wikipedia Epidermal_growth_factor

Target Cross References - Protein

canSAR P01133
CGD Hypomagnesemia 4, renal
Human Protein Atlas ENSG00000138798
IntAct P01133
PharmGKB PA27664
Reactome REACT_604 (Hemostasis.)
REACT_9417 (Signaling by EGFR.)
UniProt B4DRK7 E9PBF0 P01133 Q52LZ6

Target Cross References - Domain

InterPro IPR000033 (LDLR_classB_rpt.)
IPR000152 (EGF-type_Asp/Asn_hydroxyl_site.)
IPR000742 (EGF_3.)
IPR001881 (EGF_Ca-bd.)
IPR006209 (EGF.)
IPR006210 (EGF-like.)
IPR011042 (6-blade_b-propeller_TolB-like.)
IPR013032 (EGF-like_reg_CS.)
IPR013091 (EGF_Ca-bd_2.)
IPR016317 (Pro-epidermal_GF.)
IPR018097 (EGF_Ca-bd_CS.)
Pfam PF00008 (EGF)
PF00058 (Ldl_recept_b)
PF07645 (EGF_CA)

Target Cross References - Structure

PDBe 1IVO 1JL9 1NQL 3NJP
CREDO 1IVO 1JL9 1NQL 3NJP
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