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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5728
Target Type SINGLE PROTEIN
Preferred Name Cyclin-dependent kinase-like 2
Synonyms CDKL2 | Cyclin-dependent kinase-like 2 | Protein kinase p56 KKIAMRE | Serine/threonine-protein kinase KKIAMRE
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdkl family

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase-like 2 SINGLE PROTEIN Q92772

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000138769
Ensembl ENSG00000138769
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007548 (sex differentiation)
GO:0016310 (phosphorylation)
GO:0051726 (regulation of cell cycle)
GO:1903955 (positive regulation of protein targeting to mitochondrion)
Wikipedia CDKL2

Target Cross References - Protein

canSAR Q92772
Human Protein Atlas ENSG00000138769
IntAct Q92772
Guide to Pharmacology 1983
Open Targets ENSG00000138769
PharmGKB PA26318
Pharos Q92772 (Tbio)
UniProt B2R695 Q92772

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 4AAA 4BBM
CREDO 4AAA 4BBM
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