ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5719
Target Type SINGLE PROTEIN
Preferred Name Cell division protein kinase 8
Synonyms CDK8 | Cell division protein kinase 8 | Cyclin-dependent kinase 8 | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > cmgc protein kinase group > cmgc protein kinase cdk family > cmgc protein kinase cdk8 subfamily

Target Components

Component Description Relationship Accession
Cyclin-dependent kinase 8 SINGLE PROTEIN P49336

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3559691 Cyclin-dependent kinase PROTEIN FAMILY
CHEMBL3038474 CDK8/Cyclin C PROTEIN COMPLEX

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132964
Ensembl ENSG00000132964
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0016592 (mediator complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004693 (cyclin-dependent protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0008353 (RNA polymerase II carboxy-terminal domain kinase activity)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0006468 (protein phosphorylation)
GO:0016310 (phosphorylation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0051726 (regulation of cell cycle)
Wikipedia Cyclin-dependent_kinase_8

Target Cross References - Protein

canSAR P49336
Human Protein Atlas ENSG00000132964
IntAct P49336
Guide to Pharmacology 1980
Open Targets ENSG00000132964
PharmGKB PA26315
Pharos P49336 (Tchem)
Reactome R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-2122947 (NOTCH1 Intracellular Domain Regulates Transcription.)
R-HSA-212436 (Generic Transcription Pathway.)
R-HSA-2173796 (SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription.)
R-HSA-2644606 (Constitutive Signaling by NOTCH1 PEST Domain Mutants.)
R-HSA-2894862 (Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants.)
R-HSA-381340 (Transcriptional regulation of white adipocyte differentiation.)
UniProt P49336 Q5VUF3 Q6ISB5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)

Target Cross References - Structure

PDBe 3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP
CREDO 3RGF 4CRL 4F6S 4F6U 4F6W 4F70 4F7J 4F7L 4F7N 4F7S 4G6L 5BNJ 5CEI 5FGK 5HBE 5HBH 5HBJ 5HNB 5HVY 5I5Z 5ICP 5IDN 5IDP
spacer
spacer