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Target Report Card

Target Name and Classification

Target ID CHEMBL5716
Preferred Name Nuclear receptor subfamily 2 group C member 2
Synonyms NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Orphan nuclear receptor TAK1 | Orphan nuclear receptor TR4 | TAK1 | TR4 | Testicular receptor 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group c > nuclear hormone receptor subfamily 2 group c member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 2 group C member 2 SINGLE PROTEIN P49116

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177463
Ensembl ENSG00000177463
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO Molecular Function GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0004872 (receptor activity)
GO:0005515 (protein binding)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046872 (metal ion binding)
GO:0046982 (protein heterodimerization activity)
GO Biological Process GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006367 (transcription initiation from RNA polymerase II promoter)
GO:0007283 (spermatogenesis)
GO:0007399 (nervous system development)
GO:0021549 (cerebellum development)
GO:0030154 (cell differentiation)
GO:0038066 (p38MAPK cascade)
GO:0040019 (positive regulation of embryonic development)
GO:0043401 (steroid hormone mediated signaling pathway)
GO:0045663 (positive regulation of myoblast differentiation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0048520 (positive regulation of behavior)
GO:0051321 (meiotic cell cycle)
GO:0098779 (mitophagy in response to mitochondrial depolarization)
Wikipedia Testicular_receptor_4

Target Cross References - Protein

canSAR P49116
Human Protein Atlas ENSG00000177463
IntAct P49116
Guide to Pharmacology 614
Open Targets ENSG00000177463
PharmGKB PA31755
Pharos P49116 (Tchem)
Reactome R-HSA-383280 (Nuclear Receptor transcription pathway.)
UniProt A8K3H5 B6ZGT8 P49116 P55092

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Nuclear_hrmn_rcpt.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure