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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5716
Target Type SINGLE PROTEIN
Preferred Name Nuclear receptor subfamily 2 group C member 2
Synonyms NR2C2 | Nuclear receptor subfamily 2 group C member 2 | Orphan nuclear receptor TAK1 | Orphan nuclear receptor TR4 | TAK1 | TR4 | Testicular receptor 4
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transcription factor > nuclear receptor > nuclear hormone receptor subfamily 2 > nuclear hormone receptor subfamily 2 group c > nuclear hormone receptor subfamily 2 group c member 2

Target Components

Component Description Relationship Accession
Nuclear receptor subfamily 2 group C member 2 SINGLE PROTEIN P49116

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000177463
Ensembl ENSG00000177463
GO Cellular Component GO:0005654 (nucleoplasm)
GO Molecular Function GO:0003700 (sequence-specific DNA binding transcription factor activity)
GO:0003707 (steroid hormone receptor activity)
GO:0003713 (transcription coactivator activity)
GO:0008270 (zinc ion binding)
GO:0043565 (sequence-specific DNA binding)
GO Biological Process GO:0007283 (spermatogenesis)
GO:0007399 (nervous system development)
GO:0030154 (cell differentiation)
GO:0034339 (regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
Wikipedia Testicular_receptor_4

Target Cross References - Protein

canSAR P49116
Human Protein Atlas ENSG00000177463
IntAct P49116
Guide to Pharmacology 614 (Testicular receptor 4)
PharmGKB PA31755
Reactome REACT_71 (Gene Expression.)
UniProt A8K3H5 B6ZGT8 P49116 P55092

Target Cross References - Domain

InterPro IPR000536 (Nucl_hrmn_rcpt_lig-bd_core.)
IPR001628 (Znf_hrmn_rcpt.)
IPR001723 (Str_hrmn_rcpt.)
IPR008946 (Nucl_hormone_rcpt_ligand-bd.)
IPR013088 (Znf_NHR/GATA.)
Pfam PF00104 (Hormone_recep)
PF00105 (zf-C4)

Target Cross References - Structure

PDBe 3P0U
CREDO 3P0U
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