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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5715
Target Type SINGLE PROTEIN
Preferred Name Paxillin
Synonyms PXN | Paxillin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Paxillin SINGLE PROTEIN P49023

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089159
Ensembl ENSG00000089159
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005875 (microtubule associated complex)
GO:0005925 (focal adhesion)
GO:0030027 (lamellipodium)
GO Molecular Function GO:0008013 (beta-catenin binding)
GO:0008270 (zinc ion binding)
GO:0017166 (vinculin binding)
GO Biological Process GO:0006936 (muscle contraction)
GO:0007160 (cell-matrix adhesion)
GO:0007172 (signal complex assembly)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0034329 (cell junction assembly)
GO:0034614 (cellular response to reactive oxygen species)
GO:0060396 (growth hormone receptor signaling pathway)
Wikipedia Paxillin

Target Cross References - Protein

Human Protein Atlas ENSG00000089159
IntAct P49023
PharmGKB PA34062
Reactome REACT_17044 (Muscle contraction.)
REACT_20676 (Cell junction organization.)
REACT_9417 (Signaling by EGFR.)
UniProt B2RAI3 B7ZMB4 O14970 O14971 O60360 P49023 Q5HYA4

Target Cross References - Domain

InterPro IPR001781 (Znf_LIM.)
IPR001904 (Paxillin.)
Pfam PF00412 (LIM)

Target Cross References - Structure

PDBe 2O9V 2VZD 2VZG 2VZI 3GM1
CREDO 2O9V 2VZD 2VZG 2VZI 3GM1
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