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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5715
Target Type SINGLE PROTEIN
Preferred Name Paxillin
Synonyms PXN | Paxillin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Paxillin SINGLE PROTEIN P49023

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089159
Ensembl ENSG00000089159
GO Cellular Component GO:0001725 (stress fiber)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005856 (cytoskeleton)
GO:0005875 (microtubule associated complex)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0005938 (cell cortex)
GO:0030027 (lamellipodium)
GO:0030054 (cell junction)
GO Molecular Function GO:0005178 (integrin binding)
GO:0005515 (protein binding)
GO:0008013 (beta-catenin binding)
GO:0008270 (zinc ion binding)
GO:0017166 (vinculin binding)
GO:0019901 (protein kinase binding)
GO:0032403 (protein complex binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006936 (muscle contraction)
GO:0007155 (cell adhesion)
GO:0007160 (cell-matrix adhesion)
GO:0007165 (signal transduction)
GO:0007172 (signal complex assembly)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0034614 (cellular response to reactive oxygen species)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0060396 (growth hormone receptor signaling pathway)
Wikipedia Paxillin

Target Cross References - Protein

Human Protein Atlas ENSG00000089159
IntAct P49023
Open Targets ENSG00000089159
PharmGKB PA34062
Reactome R-HSA-180292 (GAB1 signalosome.)
R-HSA-4420097 (VEGFA-VEGFR2 Pathway.)
R-HSA-445355 (Smooth Muscle Contraction.)
R-HSA-446343 (Localization of the PINCH-ILK-PARVIN complex to focal adhesions.)
R-HSA-446388 (Regulation of cytoskeletal remodeling and cell spreading by IPP complex components.)
R-HSA-8849471 (PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases.)
UniProt B2RAI3 B7ZMB4 O14970 O14971 O60360 P49023 Q5HYA4

Target Cross References - Domain

InterPro IPR001781 (Znf_LIM.)
IPR001904 (Paxillin.)
Pfam PF00412 (LIM)

Target Cross References - Structure

PDBe 1OW6 1OW7 1OW8 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2
CREDO 1OW6 1OW7 1OW8 2O9V 2VZD 2VZG 2VZI 3GM1 3PY7 3RQE 3RQF 3RQG 3U3F 4EDN 4R32 4XGZ 4XH2
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