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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5715
Target Type SINGLE PROTEIN
Preferred Name Paxillin
Synonyms PXN | Paxillin
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Paxillin SINGLE PROTEIN P49023

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000089159
Ensembl ENSG00000089159
GO Cellular Component GO:0001725 (stress fiber)
GO:0005938 (cell cortex)
GO:0030027 (lamellipodium)
GO:0005654 (nucleoplasm)
GO:0005829 (cytosol)
GO:0005875 (microtubule associated complex)
GO:0005925 (focal adhesion)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO Molecular Function GO:0017166 (vinculin binding)
GO:0008013 (beta-catenin binding)
GO:0008270 (zinc ion binding)
GO Biological Process GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0034329 (cell junction assembly)
GO:0034614 (cellular response to reactive oxygen species)
GO:0007165 (signal transduction)
GO:0007179 (transforming growth factor beta receptor signaling pathway)
GO:0008360 (regulation of cell shape)
GO:0048754 (branching morphogenesis of an epithelial tube)
GO:0007172 (signal complex assembly)
GO:0007229 (integrin-mediated signaling pathway)
GO:0048010 (vascular endothelial growth factor receptor signaling pathway)
GO:0048041 (focal adhesion assembly)
GO:0060396 (growth hormone receptor signaling pathway)
GO:0000187 (activation of MAPK activity)
GO:0006936 (muscle contraction)
GO:0007155 (cell adhesion)
GO:0007010 (cytoskeleton organization)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0030032 (lamellipodium assembly)
GO:0034446 (substrate adhesion-dependent cell spreading)
Wikipedia Paxillin

Target Cross References - Protein

Human Protein Atlas ENSG00000089159
IntAct P49023
PharmGKB PA34062
UniProt B7ZMB4 O14970 O14971 P49023 Q5HYA4 B2RAI3 O60360

Target Cross References - Domain

InterPro IPR001904 (Paxillin.)
IPR001781 (Znf_LIM.)
Pfam PF00412 (LIM)

Target Cross References - Structure

PDBe 1OW7 1OW8 2O9V 4XGZ 4XH2 1OW6 3RQG 3GM1 3RQF 4R32 3RQE 4EDN 2VZD 2VZG 3PY7 2VZI 3U3F
CREDO 1OW7 1OW8 2O9V 4XGZ 4XH2 1OW6 3RQG 3GM1 3RQF 4R32 3RQE 4EDN 2VZD 2VZG 3PY7 2VZI 3U3F
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