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Target Report Card

Target Name and Classification

Target ID CHEMBL5714
Preferred Name Tumor necrosis factor ligand superfamily member 6
Synonyms ADAM10-processed FasL form | APL | APT1LG1 | APTL | Apoptosis antigen ligand | CD95 ligand | CD95-L | CD95L | CD_antigen=CD178 | FASL | FASLG | Fas antigen ligand | Fas ligand | FasL | FasL ICD | FasL intracellular domain | Receptor-binding FasL ectodomain | SPA | SPPL2A-processed FasL form | Soluble Fas ligand | TNFSF6 | Tumor necrosis factor ligand superfamily member 6 | Tumor necrosis factor ligand superfamily member 6, membrane form | Tumor necrosis factor ligand superfamily member 6, soluble form | sFasL
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Tumor necrosis factor ligand superfamily member 6 SINGLE PROTEIN P48023

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117560
Ensembl ENSG00000117560
GO Cellular Component GO:0005615 (extracellular space)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0005125 (cytokine activity)
GO Biological Process GO:0006919 (activation of caspase activity)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0008633 (activation of pro-apoptotic gene products)
GO:0016525 (negative regulation of angiogenesis)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB cascade)
GO:0060554 (induction of necroptosis of activated-T cells)
GO:0060555 (induction of necroptosis by extracellular signals)
GO:0070265 (necrotic cell death)
Wikipedia Fas_ligand

Target Cross References - Protein

canSAR P48023
Human Protein Atlas ENSG00000117560
IntAct P48023
PharmGKB PA56
Reactome REACT_578 (Apoptosis.)
UniProt P48023 Q9BZP9

Target Cross References - Domain

InterPro IPR006052 (TNF_family.)
IPR006053 (TNF_a/b/c.)
IPR008064 (Fas_ligand.)
IPR008983 (Tumour_necrosis_fac-like.)
IPR021184 (TNF_CS.)
Pfam PF00229 (TNF)