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Target Report Card

Target Name and Classification

Target ID CHEMBL5714
Target Type SINGLE PROTEIN
Preferred Name Tumor necrosis factor ligand superfamily member 6
Synonyms ADAM10-processed FasL form | APL | APT1LG1 | APTL | Apoptosis antigen ligand | CD95 ligand | CD95-L | CD95L | CD_antigen=CD178 | FASL | FASLG | Fas antigen ligand | Fas ligand | FasL ICD | FasL intracellular domain | FasL | Receptor-binding FasL ectodomain | SPA | SPPL2A-processed FasL form | Soluble Fas ligand | TNFSF6 | Tumor necrosis factor ligand superfamily member 6 | Tumor necrosis factor ligand superfamily member 6, membrane form | Tumor necrosis factor ligand superfamily member 6, soluble form | sFasL
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Tumor necrosis factor ligand superfamily member 6 SINGLE PROTEIN P48023

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000117560
Ensembl ENSG00000117560
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005634 (nucleus)
GO:0005764 (lysosome)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0005901 (caveola)
GO:0009897 (external side of plasma membrane)
GO:0009986 (cell surface)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0016023 (cytoplasmic, membrane-bounded vesicle)
GO:0031410 (cytoplasmic vesicle)
GO:0043202 (lysosomal lumen)
GO:0045121 (membrane raft)
GO:0048471 (perinuclear region of cytoplasm)
GO:0060205 (cytoplasmic membrane-bounded vesicle lumen)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005102 (receptor binding)
GO:0005123 (death receptor binding)
GO:0005125 (cytokine activity)
GO:0005164 (tumor necrosis factor receptor binding)
GO:0005515 (protein binding)
GO Biological Process GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006925 (inflammatory cell apoptotic process)
GO:0006955 (immune response)
GO:0007165 (signal transduction)
GO:0007267 (cell-cell signaling)
GO:0008284 (positive regulation of cell proliferation)
GO:0008625 (extrinsic apoptotic signaling pathway via death domain receptors)
GO:0016525 (negative regulation of angiogenesis)
GO:0030644 (cellular chloride ion homeostasis)
GO:0032496 (response to lipopolysaccharide)
GO:0043065 (positive regulation of apoptotic process)
GO:0043123 (positive regulation of I-kappaB kinase/NF-kappaB signaling)
GO:0043525 (positive regulation of neuron apoptotic process)
GO:0045742 (positive regulation of epidermal growth factor receptor signaling pathway)
GO:0046666 (retinal cell programmed cell death)
GO:0048388 (endosomal lumen acidification)
GO:0070231 (T cell apoptotic process)
GO:0070266 (necroptotic process)
GO:0070848 (response to growth factor)
GO:0097190 (apoptotic signaling pathway)
GO:0097191 (extrinsic apoptotic signaling pathway)
GO:0097296 (activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway)
GO:0097527 (necroptotic signaling pathway)
GO:1902041 (regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:1902042 (negative regulation of extrinsic apoptotic signaling pathway via death domain receptors)
GO:2000353 (positive regulation of endothelial cell apoptotic process)
Wikipedia Fas_ligand

Target Cross References - Protein

canSAR P48023
Human Protein Atlas ENSG00000117560
IntAct P48023
Open Targets ENSG00000117560
PharmGKB PA56
Reactome R-HSA-140534 (Ligand-dependent caspase activation.)
R-HSA-3371378 (Regulation by c-FLIP.)
R-HSA-5213460 (RIPK1-mediated regulated necrosis.)
R-HSA-5218900 (CASP8 activity is inhibited.)
R-HSA-6785807 (Interleukin-4 and 13 signaling.)
R-HSA-69416 (Dimerization of procaspase-8.)
R-HSA-75157 (FasL/ CD95L signaling.)
R-HSA-8862803 (Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models.)
UniProt P48023 Q9BZP9

Target Cross References - Domain

InterPro IPR006052 (TNF_dom.)
IPR006053 (TNF.)
IPR008983 (Tumour_necrosis_fac-like_dom.)
IPR021184 (TNF_CS.)
IPR028326 (FASL.)
Pfam PF00229 (TNF)

Target Cross References - Structure

PDBe 4MSV 5L19 5L36
CREDO 4MSV 5L19 5L36
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