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Target Report Card

Target Name and Classification

Target ID CHEMBL5705
Preferred Name Egl nine homolog 3
Synonyms EGLN3 | Egl nine homolog 3 | HIF-PH3 | HIF-prolyl hydroxylase 3 | HPH-1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase 3 | PHD3 | Prolyl hydroxylase domain-containing protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Egl nine homolog 3 SINGLE PROTEIN Q9H6Z9

Target Relations

ChEMBL ID Pref Name Target Type
CHEMBL3831261 Hypoxia-inducible factor prolyl hydroxylase PROTEIN FAMILY

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129521
Ensembl ENSG00000129521
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO Molecular Function GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0016491 (oxidoreductase activity)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0016706 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors)
GO:0031418 (L-ascorbic acid binding)
GO:0031545 (peptidyl-proline 4-dioxygenase activity)
GO:0046872 (metal ion binding)
GO:0051213 (dioxygenase activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0006915 (apoptotic process)
GO:0006919 (activation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0006974 (cellular response to DNA damage stimulus)
GO:0018126 (protein hydroxylation)
GO:0018401 (peptidyl-proline hydroxylation to 4-hydroxy-L-proline)
GO:0042127 (regulation of cell proliferation)
GO:0043523 (regulation of neuron apoptotic process)
GO:0055114 (oxidation-reduction process)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
Wikipedia EGLN3

Target Cross References - Protein

canSAR Q9H6Z9
Human Protein Atlas ENSG00000129521
IntAct Q9H6Z9
Guide to Pharmacology 2834
Open Targets ENSG00000129521
PharmGKB PA27672
Reactome R-HSA-1234176 (Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha.)
UniProt Q2TA79 Q3B8N4 Q6P1R2 Q9H6Z9

Target Cross References - Domain

InterPro IPR005123 (Oxoglu/Fe-dep_dioxygenase.)
IPR006620 (Pro_4_hyd_alph.)
Pfam PF13640 (2OG-FeII_Oxy_3)