ChEMBL logo

ChEMBL

spacer
ChEMBL Statistics
  Loading Statistics...
spacer

Target Report Card

Target Name and Classification

Target ID CHEMBL5705
Target Type SINGLE PROTEIN
Preferred Name Egl nine homolog 3
Synonyms EGLN3 | Egl nine homolog 3 | HIF-PH3 | HIF-prolyl hydroxylase 3 | HPH-1 | HPH-3 | Hypoxia-inducible factor prolyl hydroxylase 3 | PHD3 | Prolyl hydroxylase domain-containing protein 3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme

Target Components

Component Description Relationship Accession
Egl nine homolog 3 SINGLE PROTEIN Q9H6Z9

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000129521
Ensembl ENSG00000129521
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO Molecular Function GO:0005506 (iron ion binding)
GO:0005515 (protein binding)
GO:0016702 (oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen)
GO:0016705 (oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen)
GO:0031418 (L-ascorbic acid binding)
GO Biological Process GO:0006915 (apoptosis)
Wikipedia EGLN3

Target Cross References - Protein

canSAR Q9H6Z9
Human Protein Atlas ENSG00000129521
IntAct Q9H6Z9
PharmGKB PA27672
UniProt Q2TA79 Q3B8N4 Q6P1R2 Q9H6Z9

Target Cross References - Domain

InterPro IPR005123 (Oxoglutarate/Fe-dep_oxygenase.)
IPR006620 (Pro_4_hyd_alph.)
Pfam PF03171 (2OG-FeII_Oxy)
spacer
spacer