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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5698
Target Type SINGLE PROTEIN
Preferred Name NUAK family SNF1-like kinase 2
Synonyms NUAK family SNF1-like kinase 2 | NUAK2 | OMPHK2 | Omphalocele kinase 2 | SNARK | SNARK | SNF1/AMP kinase-related kinase
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase camk1 family > camk protein kinase nuak subfamily

Target Components

Component Description Relationship Accession
NUAK family SNF1-like kinase 2 SINGLE PROTEIN Q9H093

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000163545
Ensembl ENSG00000163545
GO Cellular Component GO:0005737 (cytoplasm)
GO:0031588 (nucleotide-activated protein kinase complex)
GO Molecular Function GO:0000287 (magnesium ion binding)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptosis)
GO:0006915 (apoptotic process)
GO:0030036 (actin cytoskeleton organization)
GO:0032007 (negative regulation of TOR signaling)
GO:0035556 (intracellular signal transduction)
GO:0042149 (cellular response to glucose starvation)
GO:0043066 (negative regulation of apoptosis)
GO:0043066 (negative regulation of apoptotic process)
Wikipedia NUAK2

Target Cross References - Protein

canSAR Q9H093
Human Protein Atlas ENSG00000163545
IntAct Q9H093
PharmGKB PA142671243
UniProt Q9H093

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
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