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Target Report Card

Target Name and Classification

Target ID CHEMBL5692
Target Type SINGLE PROTEIN
Preferred Name Pituitary adenylate cyclase-activating polypeptide
Synonyms ADCYAP1 | PACAP | PACAP-27 | PACAP-38 | PACAP-related peptide | PACAP27 | PACAP38 | PRP-48 | Pituitary adenylate cyclase-activating polypeptide 27 | Pituitary adenylate cyclase-activating polypeptide 38 | Pituitary adenylate cyclase-activating polypeptide
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Pituitary adenylate cyclase-activating polypeptide SINGLE PROTEIN P18509

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000141433
Ensembl ENSG00000141433
GO Cellular Component GO:0005576 (extracellular region)
GO:0005615 (extracellular space)
GO:0005622 (intracellular)
GO:0043195 (terminal bouton)
GO Molecular Function GO:0005057 (receptor signaling protein activity)
GO:0005102 (receptor binding)
GO:0005179 (hormone activity)
GO:0005184 (neuropeptide hormone activity)
GO:0005515 (protein binding)
GO:0016521 (pituitary adenylate cyclase activating polypeptide activity)
GO:0031858 (pituitary adenylate cyclase-activating polypeptide receptor binding)
GO:0051428 (peptide hormone receptor binding)
GO Biological Process GO:0001541 (ovarian follicle development)
GO:0001662 (behavioral fear response)
GO:0001821 (histamine secretion)
GO:0002865 (negative regulation of acute inflammatory response to antigenic stimulus)
GO:0002878 (negative regulation of acute inflammatory response to non-antigenic stimulus)
GO:0007190 (activation of adenylate cyclase activity)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007218 (neuropeptide signaling pathway)
GO:0007267 (cell-cell signaling)
GO:0007399 (nervous system development)
GO:0007565 (female pregnancy)
GO:0008277 (regulation of G-protein coupled receptor protein signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0010579 (positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway)
GO:0010628 (positive regulation of gene expression)
GO:0010656 (negative regulation of muscle cell apoptotic process)
GO:0010976 (positive regulation of neuron projection development)
GO:0019233 (sensory perception of pain)
GO:0019933 (cAMP-mediated signaling)
GO:0021983 (pituitary gland development)
GO:0030819 (positive regulation of cAMP biosynthetic process)
GO:0031175 (neuron projection development)
GO:0032755 (positive regulation of interleukin-6 production)
GO:0032880 (regulation of protein localization)
GO:0034260 (negative regulation of GTPase activity)
GO:0042594 (response to starvation)
GO:0043267 (negative regulation of potassium ion transport)
GO:0043547 (positive regulation of GTPase activity)
GO:0045471 (response to ethanol)
GO:0045786 (negative regulation of cell cycle)
GO:0045860 (positive regulation of protein kinase activity)
GO:0045909 (positive regulation of vasodilation)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046034 (ATP metabolic process)
GO:0051968 (positive regulation of synaptic transmission, glutamatergic)
GO:0060078 (regulation of postsynaptic membrane potential)
GO:0060124 (positive regulation of growth hormone secretion)
GO:0060253 (negative regulation of glial cell proliferation)
GO:0070374 (positive regulation of ERK1 and ERK2 cascade)
GO:0070445 (regulation of oligodendrocyte progenitor proliferation)
GO:0071385 (cellular response to glucocorticoid stimulus)
GO:0071651 (positive regulation of chemokine (C-C motif) ligand 5 production)
GO:0090274 (positive regulation of somatostatin secretion)
Wikipedia Pituitary_adenylate_cyclase-activating_peptide

Target Cross References - Protein

canSAR P18509
Human Protein Atlas ENSG00000141433
IntAct P18509
Open Targets ENSG00000141433
PharmGKB PA24564
Reactome R-HSA-187024 (NGF-independant TRKA activation.)
R-HSA-418555 (G alpha (s) signalling events.)
R-HSA-420092 (Glucagon-type ligand receptors.)
UniProt B2R7N4 P18509 Q52LQ0

Target Cross References - Domain

InterPro IPR000532 (Glucagon_GIP_secretin_VIP.)
Pfam PF00123 (Hormone_2)
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