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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5683
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase DCLK1
Synonyms DCAMKL1 | DCDC3A | DCLK1 | Doublecortin domain-containing protein 3A | Doublecortin-like and CAM kinase-like 1 | Doublecortin-like kinase 1 | KIAA0369 | Serine/threonine-protein kinase DCLK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > camk protein kinase group > camk protein kinase dcamk1 family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase DCLK1 SINGLE PROTEIN O15075

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000133083
Ensembl ENSG00000133083
GO Cellular Component GO:0005887 (integral component of plasma membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005057 (receptor signaling protein activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0001764 (neuron migration)
GO:0006468 (protein phosphorylation)
GO:0007275 (multicellular organism development)
GO:0007399 (nervous system development)
GO:0007409 (axonogenesis)
GO:0007417 (central nervous system development)
GO:0007420 (brain development)
GO:0009615 (response to virus)
GO:0016197 (endosomal transport)
GO:0016310 (phosphorylation)
GO:0021952 (central nervous system projection neuron axonogenesis)
GO:0030154 (cell differentiation)
GO:0030900 (forebrain development)
GO:0035556 (intracellular signal transduction)
GO:0048675 (axon extension)
GO:0048813 (dendrite morphogenesis)
Wikipedia DCLK1

Target Cross References - Protein

canSAR O15075
Human Protein Atlas ENSG00000133083
IntAct O15075
Guide to Pharmacology 2005
Open Targets ENSG00000133083
PharmGKB PA162383325
Pharos O15075 (Tchem)
UniProt B7Z3E9 O15075 Q5VZY8 Q5VZZ0 Q5VZZ1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR003533 (Doublecortin_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020636 (Ca/CaM-dep_Ca-dep_prot_Kinase.)
Pfam PF00069 (Pkinase)
PF03607 (DCX)

Target Cross References - Structure

PDBe 1MFW 1MG4 5JZJ 5JZN
CREDO 1MFW 1MG4 5JZJ 5JZN
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