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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5679
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase Nek3
Synonyms HSPK 36 | NEK3 | Never in mitosis A-related kinase 3 | NimA-related protein kinase 3 | Serine/threonine-protein kinase Nek3
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase nek family > other protein kinase nek1

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase Nek3 SINGLE PROTEIN P51956

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000136098
Ensembl ENSG00000136098
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005813 (centrosome)
GO:0030424 (axon)
GO:0042995 (cell projection)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO:0046872 (metal ion binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007017 (microtubule-based process)
GO:0007049 (cell cycle)
GO:0007059 (chromosome segregation)
GO:0007067 (mitotic nuclear division)
GO:0016310 (phosphorylation)
GO:0030010 (establishment of cell polarity)
GO:0048812 (neuron projection morphogenesis)
GO:0051301 (cell division)
GO:0090043 (regulation of tubulin deacetylation)
Wikipedia NEK3

Target Cross References - Protein

canSAR P51956
Human Protein Atlas ENSG00000136098
IntAct P51956
Guide to Pharmacology 2118
Open Targets ENSG00000136098
PharmGKB PA31547
Pharos P51956 (Tbio)
UniProt A8K2J4 P51956 Q5TAP2 Q8J023 Q8WUN5

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF00069 (Pkinase)
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