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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5678
Target Type SINGLE PROTEIN
Preferred Name G protein-coupled receptor kinase 5
Synonyms G protein-coupled receptor kinase 5 | G protein-coupled receptor kinase GRK5 | GPRK5 | GRK5
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > agc protein kinase group > agc protein kinase grk family > agc protein kinase grk subfamily

Target Components

Component Description Relationship Accession
G protein-coupled receptor kinase 5 SINGLE PROTEIN P34947

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000198873
Ensembl ENSG00000198873
GO Cellular Component GO:0005625 (soluble fraction)
GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005886 (plasma membrane)
GO:0005925 (focal adhesion)
GO:0031965 (nuclear membrane)
GO Molecular Function GO:0004674 (protein serine/threonine kinase activity)
GO:0004703 (G-protein coupled receptor kinase activity)
GO:0004871 (signal transducer activity)
GO:0005080 (protein kinase C binding)
GO:0005524 (ATP binding)
GO:0005543 (phospholipid binding)
GO:0047696 (beta-adrenergic receptor kinase activity)
GO Biological Process GO:0002029 (desensitization of G-protein coupled receptor protein signaling pathway)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007188 (G-protein signaling, coupled to cAMP nucleotide second messenger)
GO:0007188 (adenylate cyclase-modulating G-protein coupled receptor signaling pathway)
GO:0007217 (tachykinin receptor signaling pathway)
GO:0008277 (regulation of G-protein coupled receptor protein signaling pathway)
GO:0008284 (positive regulation of cell proliferation)
GO:0016055 (Wnt signaling pathway)
GO:0042493 (response to drug)
GO:0043066 (negative regulation of apoptotic process)
GO:0045444 (fat cell differentiation)
GO:0046777 (protein autophosphorylation)
GO:0051726 (regulation of cell cycle)
Wikipedia GRK5

Target Cross References - Protein

canSAR P34947
Human Protein Atlas ENSG00000198873
IntAct P34947
PharmGKB PA180
UniProt D3DRD0 P34947 Q5T059

Target Cross References - Domain

InterPro IPR000239 (GPCR_kinase.)
IPR000342 (Regulat_G_prot_signal.)
IPR000719 (Prot_kinase_cat_dom.)
IPR000719 (Prot_kinase_dom.)
IPR000961 (AGC-kinase_C.)
IPR002290 (Ser/Thr_dual-sp_kinase.)
IPR002290 (Ser/Thr_prot_kinase_dom.)
IPR011009 (Kinase-like_dom.)
IPR016137 (RGS.)
IPR016137 (Regulat_G_prot_signal_superfam.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF00615 (RGS)

Target Cross References - Structure

PDBe 4TNB 4TND
CREDO 4TNB 4TND
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