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Target Report Card

Target Name and Classification

Target ID CHEMBL5666
Preferred Name Disks large homolog 4
Synonyms DLG4 | Disks large homolog 4 | PSD-95 | PSD95 | Postsynaptic density protein 95 | SAP-90 | SAP90 | Synapse-associated protein 90
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Disks large homolog 4 SINGLE PROTEIN P78352

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000132535
Ensembl ENSG00000132535
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005783 (endoplasmic reticulum)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0008021 (synaptic vesicle)
GO:0008076 (voltage-gated potassium channel complex)
GO:0008328 (ionotropic glutamate receptor complex)
GO:0014069 (postsynaptic density)
GO:0016020 (membrane)
GO:0016323 (basolateral plasma membrane)
GO:0030054 (cell junction)
GO:0030424 (axon)
GO:0030425 (dendrite)
GO:0030666 (endocytic vesicle membrane)
GO:0030863 (cortical cytoskeleton)
GO:0031234 (extrinsic component of cytoplasmic side of plasma membrane)
GO:0032281 (AMPA glutamate receptor complex)
GO:0032839 (dendrite cytoplasm)
GO:0042995 (cell projection)
GO:0043197 (dendritic spine)
GO:0044224 (juxtaparanode region of axon)
GO:0044300 (cerebellar mossy fiber)
GO:0044306 (neuron projection terminus)
GO:0044309 (neuron spine)
GO:0045202 (synapse)
GO:0045211 (postsynaptic membrane)
GO:0060076 (excitatory synapse)
GO:0071944 (cell periphery)
GO:0097060 (synaptic membrane)
GO:0098794 (postsynapse)
GO:0098839 (postsynaptic density membrane)
GO Molecular Function GO:0004385 (guanylate kinase activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005515 (protein binding)
GO:0008022 (protein C-terminus binding)
GO:0015276 (ligand-gated ion channel activity)
GO:0019900 (kinase binding)
GO:0019903 (protein phosphatase binding)
GO:0030165 (PDZ domain binding)
GO:0031697 (beta-1 adrenergic receptor binding)
GO:0031748 (D1 dopamine receptor binding)
GO:0031812 (P2Y1 nucleotide receptor binding)
GO:0033130 (acetylcholine receptor binding)
GO:0035255 (ionotropic glutamate receptor binding)
GO:0044877 (macromolecular complex binding)
GO:0097109 (neuroligin family protein binding)
GO:0097110 (scaffold protein binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0002091 (negative regulation of receptor internalization)
GO:0007165 (signal transduction)
GO:0007204 (positive regulation of cytosolic calcium ion concentration)
GO:0007268 (chemical synaptic transmission)
GO:0007399 (nervous system development)
GO:0007612 (learning)
GO:0016188 (synaptic vesicle maturation)
GO:0034220 (ion transmembrane transport)
GO:0035176 (social behavior)
GO:0035418 (protein localization to synapse)
GO:0035641 (locomotory exploration behavior)
GO:0035865 (cellular response to potassium ion)
GO:0045184 (establishment of protein localization)
GO:0045197 (establishment or maintenance of epithelial cell apical/basal polarity)
GO:0046037 (GMP metabolic process)
GO:0046710 (GDP metabolic process)
GO:0048169 (regulation of long-term neuronal synaptic plasticity)
GO:0050806 (positive regulation of synaptic transmission)
GO:0050885 (neuromuscular process controlling balance)
GO:0060997 (dendritic spine morphogenesis)
GO:0061098 (positive regulation of protein tyrosine kinase activity)
GO:0065003 (protein-containing complex assembly)
GO:0071625 (vocalization behavior)
GO:0097113 (AMPA glutamate receptor clustering)
GO:0097120 (receptor localization to synapse)
GO:0150012 (positive regulation of neuron projection arborization)
GO:2000310 (regulation of N-methyl-D-aspartate selective glutamate receptor activity)
GO:2000463 (positive regulation of excitatory postsynaptic potential)
GO:2000821 (regulation of grooming behavior)
Wikipedia DLG4

Target Cross References - Protein

canSAR P78352
Human Protein Atlas ENSG00000132535
IntAct P78352
Open Targets ENSG00000132535
PharmGKB PA27359
Reactome R-HSA-399719 (Trafficking of AMPA receptors.)
R-HSA-438066 (Unblocking of NMDA receptor, glutamate binding and activation.)
R-HSA-442729 (CREB phosphorylation through the activation of CaMKII.)
R-HSA-442982 (Ras activation upon Ca2+ influx through NMDA receptor.)
R-HSA-447038 (NrCAM interactions.)
R-HSA-451308 (Activation of Ca-permeable Kainate Receptor.)
R-HSA-5625900 (RHO GTPases activate CIT.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-5682910 (LGI-ADAM interactions.)
R-HSA-6794361 (Neurexins and neuroligins.)
R-HSA-8849932 (Synaptic adhesion-like molecules.)
UniProt B7Z1S1 G5E939 P78352 Q92941 Q9UKK8

Target Cross References - Domain

InterPro IPR001452 (SH3_domain.)
IPR001478 (PDZ.)
IPR008144 (Guanylate_kin-like_dom.)
IPR008145 (GK/Ca_channel_bsu.)
IPR016313 (DLG1-like.)
IPR019583 (PDZ_assoc.)
IPR019590 (DLG1_PEST_dom.)
IPR020590 (Guanylate_kinase_CS.)
IPR027417 (P-loop_NTPase.)
IPR036028 (SH3-like_dom_sf.)
IPR036034 (PDZ_sf.)
Pfam PF00018 (SH3_1)
PF00595 (PDZ)
PF00625 (Guanylate_kin)
PF10600 (PDZ_assoc)

Target Cross References - Structure

PDBe 3I4W 3K82 3ZRT 5JXB