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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5661
Target Type SINGLE PROTEIN
Preferred Name Exportin-1
Synonyms CRM1 | Chromosome region maintenance 1 protein homolog | Exp1 | Exportin-1 | XPO1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Exportin-1 SINGLE PROTEIN O14980

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000082898
Ensembl ENSG00000082898
GO Cellular Component GO:0000776 (kinetochore)
GO:0005634 (nucleus)
GO:0005635 (nuclear envelope)
GO:0005642 (annulate lamellae)
GO:0005654 (nucleoplasm)
GO:0005730 (nucleolus)
GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0015030 (Cajal body)
GO:0016020 (membrane)
GO:0030529 (intracellular ribonucleoprotein complex)
GO:0031965 (nuclear membrane)
GO:0043231 (intracellular membrane-bounded organelle)
GO Molecular Function GO:0003723 (RNA binding)
GO:0005215 (transporter activity)
GO:0005487 (nucleocytoplasmic transporter activity)
GO:0005515 (protein binding)
GO:0008536 (Ran GTPase binding)
GO:0008565 (protein transporter activity)
GO:0019904 (protein domain specific binding)
GO Biological Process GO:0000055 (ribosomal large subunit export from nucleus)
GO:0000056 (ribosomal small subunit export from nucleus)
GO:0000122 (negative regulation of transcription from RNA polymerase II promoter)
GO:0006611 (protein export from nucleus)
GO:0006810 (transport)
GO:0006886 (intracellular protein transport)
GO:0007062 (sister chromatid cohesion)
GO:0010824 (regulation of centrosome duplication)
GO:0015031 (protein transport)
GO:0016032 (viral process)
GO:0034504 (protein localization to nucleus)
GO:0042176 (regulation of protein catabolic process)
GO:0042493 (response to drug)
GO:0043488 (regulation of mRNA stability)
GO:0046825 (regulation of protein export from nucleus)
GO:0051028 (mRNA transport)
GO:0075733 (intracellular transport of virus)
Wikipedia XPO1

Target Cross References - Protein

canSAR O14980
Human Protein Atlas ENSG00000082898
IntAct O14980
Open Targets ENSG00000082898
PharmGKB PA37418
Reactome R-HSA-165054 (Rev-mediated nuclear export of HIV RNA.)
R-HSA-168333 (NEP/NS2 Interacts with the Cellular Export Machinery.)
R-HSA-2173788 (Downregulation of TGF-beta receptor signaling.)
R-HSA-2467813 (Separation of Sister Chromatids.)
R-HSA-2500257 (Resolution of Sister Chromatid Cohesion.)
R-HSA-3769402 (Deactivation of the beta-catenin transactivating complex.)
R-HSA-450520 (HuR (ELAVL1) binds and stabilizes mRNA.)
R-HSA-5663220 (RHO GTPases Activate Formins.)
R-HSA-68877 (Mitotic Prometaphase.)
R-HSA-69273 (Cyclin A/B1 associated events during G2/M transition.)
TIMBAL CRM1
UniProt A6NL14 A8K1K5 D6W5E2 O14980 Q63HP8 Q68CP3 Q99433

Target Cross References - Domain

InterPro IPR001494 (Importin-beta_N.)
IPR011989 (ARM-like.)
IPR013598 (Exportin-1/Importin-b-like.)
IPR014877 (CRM1_C_dom.)
IPR016024 (ARM-type_fold.)
Pfam PF03810 (IBN_N)
PF08389 (Xpo1)
PF08767 (CRM1_C)

Target Cross References - Structure

PDBe 1W9C 3GB8 4BSM 4BSN 5DIS
CREDO 1W9C 3GB8 4BSM 4BSN 5DIS
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