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Target Report Card

Target Name and Classification

Target ID CHEMBL5642
Preferred Name Activin receptor type-1C
Synonyms ACTR-IC | ACVR1C | ALK-7 | ALK7 | Activin receptor type IC | Activin receptor type-1C | Activin receptor-like kinase 7
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr1

Target Components

Component Description Relationship Accession
Activin receptor type-1C SINGLE PROTEIN Q8NER5

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000123612
Ensembl ENSG00000123612
GO Cellular Component GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0048179 (activin receptor complex)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0004675 (transmembrane receptor protein serine/threonine kinase activity)
GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016361 (activin receptor activity, type I)
GO:0016740 (transferase activity)
GO:0019838 (growth factor binding)
GO:0038100 (nodal binding)
GO:0046872 (metal ion binding)
GO Biological Process GO:0002021 (response to dietary excess)
GO:0006468 (protein phosphorylation)
GO:0006915 (apoptotic process)
GO:0007178 (transmembrane receptor protein serine/threonine kinase signaling pathway)
GO:0009749 (response to glucose)
GO:0016310 (phosphorylation)
GO:0019915 (lipid storage)
GO:0023014 (signal transduction by protein phosphorylation)
GO:0030154 (cell differentiation)
GO:0030262 (apoptotic nuclear changes)
GO:0032868 (response to insulin)
GO:0038092 (nodal signaling pathway)
GO:0043280 (positive regulation of cysteine-type endopeptidase activity involved in apoptotic process)
GO:0046676 (negative regulation of insulin secretion)
GO:1901164 (negative regulation of trophoblast cell migration)
GO:1901383 (negative regulation of chorionic trophoblast cell proliferation)
Wikipedia ACVR1C

Target Cross References - Protein

Human Protein Atlas ENSG00000123612
IntAct Q8NER5
Open Targets ENSG00000123612
PharmGKB PA134908988
Pharos Q8NER5 (Tbio)
Reactome R-HSA-1181150 (Signaling by NODAL.)
R-HSA-1433617 (Regulation of signaling by NODAL.)
R-HSA-1502540 (Signaling by Activin.)
UniProt Q4ZFZ8 Q86UL1 Q86UL2 Q8NER5 Q8TBG2

Target Cross References - Domain

InterPro IPR000333 (TGFB_receptor.)
IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR003605 (GS_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
Pfam PF07714 (Pkinase_Tyr)
PF08515 (TGF_beta_GS)