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Target Report Card

Target Name and Classification

Target ID CHEMBL5641
Preferred Name V-type proton ATPase subunit B, brain isoform
Synonyms ATP6B2 | ATP6V1B2 | Endomembrane proton pump 58 kDa subunit | HO57 | V-ATPase subunit B 2 | V-type proton ATPase subunit B, brain isoform | VPP3 | Vacuolar proton pump subunit B 2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • transporter > primary active transporter > f-type and v-type atpases > v-type atpase
  • enzyme > hydrolase

Target Components

Component Description Relationship Accession
V-type proton ATPase subunit B, brain isoform SINGLE PROTEIN P21281

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000147416
Ensembl ENSG00000147416
GO Cellular Component GO:0001726 (ruffle)
GO:0005737 (cytoplasm)
GO:0005765 (lysosomal membrane)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0005902 (microvillus)
GO:0012505 (endomembrane system)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO:0033180 (proton-transporting V-type ATPase, V1 domain)
GO:0042470 (melanosome)
GO:0043209 (myelin sheath)
GO:0043231 (intracellular membrane-bounded organelle)
GO:0070062 (extracellular exosome)
GO Molecular Function GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0015078 (hydrogen ion transmembrane transporter activity)
GO:0016787 (hydrolase activity)
GO:0016820 (hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances)
GO:0046961 (proton-transporting ATPase activity, rotational mechanism)
GO Biological Process GO:0006810 (transport)
GO:0006811 (ion transport)
GO:0008286 (insulin receptor signaling pathway)
GO:0015991 (ATP hydrolysis coupled proton transport)
GO:0015992 (proton transport)
GO:0016241 (regulation of macroautophagy)
GO:0033572 (transferrin transport)
GO:0034220 (ion transmembrane transport)
GO:0046034 (ATP metabolic process)
GO:0090383 (phagosome acidification)
Wikipedia ATP6V1B2

Target Cross References - Protein

canSAR P21281
Human Protein Atlas ENSG00000147416
IntAct P21281
Guide to Pharmacology 812
Open Targets ENSG00000147416
PharmGKB PA25155
Reactome R-HSA-1222556 (ROS, RNS production in response to bacteria.)
R-HSA-77387 (Insulin receptor recycling.)
R-HSA-917977 (Transferrin endocytosis and recycling.)
R-HSA-983712 (Ion channel transport.)
UniProt B2R5Z3 D3DSQ5 P21281 Q14544 Q15859 Q96IR0

Target Cross References - Domain

InterPro IPR000194 (ATPase_F1/V1/A1_a/bsu_nucl-bd.)
IPR004100 (ATPase_F1_a/bsu_N.)
IPR005723 (ATPase_V1-cplx_bsu.)
IPR020003 (ATPase_a/bsu_AS.)
IPR022879 (V-ATPase_su_B/beta.)
IPR027417 (P-loop_NTPase.)
Pfam PF00006 (ATP-synt_ab)
PF02874 (ATP-synt_ab_N)