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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5639
Target Type SINGLE PROTEIN
Preferred Name Serine/threonine-protein kinase WNK2
Synonyms Antigen NY-CO-43 | KIAA1760 | PRKWNK2 | Protein kinase lysine-deficient 2 | Protein kinase with no lysine 2 | SDCCAG43 | Serine/threonine-protein kinase WNK2 | Serologically defined colon cancer antigen 43 | WNK2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > other protein kinase group > other protein kinase wnk family

Target Components

Component Description Relationship Accession
Serine/threonine-protein kinase WNK2 SINGLE PROTEIN Q9Y3S1

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000165238
Ensembl ENSG00000165238
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0016020 (membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004674 (protein serine/threonine kinase activity)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0008285 (negative regulation of cell proliferation)
GO:0016310 (phosphorylation)
GO:0035556 (intracellular signal transduction)
GO:0046777 (protein autophosphorylation)
GO:0070373 (negative regulation of ERK1 and ERK2 cascade)
GO:2000021 (regulation of ion homeostasis)
GO:2000651 (positive regulation of sodium ion transmembrane transporter activity)
Wikipedia WNK2

Target Cross References - Protein

canSAR Q9Y3S1
Human Protein Atlas ENSG00000165238
IntAct Q9Y3S1
Guide to Pharmacology 2281
Open Targets ENSG00000165238
PharmGKB PA33783
Pharos Q9Y3S1 (Tbio)
Reactome R-HSA-2672351 (Stimuli-sensing channels.)
UniProt Q5VWF1 Q5VWF2 Q8IY36 Q9C0A3 Q9H3P4 Q9Y3S1

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR008271 (Ser/Thr_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR024678 (Kinase_OSR1/WNK_CCT.)
Pfam PF00069 (Pkinase)
PF12202 (OSR1_C)
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