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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5627
Target Type SINGLE PROTEIN
Preferred Name Leukocyte tyrosine kinase receptor
Synonyms LTK | Leukocyte tyrosine kinase receptor | Protein tyrosine kinase 1 | TYK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase alk family

Target Components

Component Description Relationship Accession
Leukocyte tyrosine kinase receptor SINGLE PROTEIN P29376

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000062524
Ensembl ENSG00000062524
GO Cellular Component GO:0005625 (soluble fraction)
GO:0005887 (integral to plasma membrane)
GO Molecular Function GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005524 (ATP binding)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0006915 (apoptosis)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008283 (cell proliferation)
GO:0014065 (phosphatidylinositol 3-kinase cascade)
Wikipedia Leukocyte_receptor_tyrosine_kinase

Target Cross References - Protein

canSAR P29376
Human Protein Atlas ENSG00000062524
Guide to Pharmacology 1838 (leukocyte receptor tyrosine kinase)
PharmGKB PA30483
UniProt A6NNJ8 P29376

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_cat_dom.)
IPR001245 (Ser-Thr/Tyr-Pkinase.)
IPR002011 (Tyr_prot_kinase_rcpt_2_CS.)
IPR008266 (Tyr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_Pkinase_cat_dom.)
Pfam PF07714 (Pkinase_Tyr)
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