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Target Report Card

Target Name and Classification

Target ID CHEMBL5627
Preferred Name Leukocyte tyrosine kinase receptor
Synonyms LTK | Leukocyte tyrosine kinase receptor | Protein tyrosine kinase 1 | TYK1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tk protein kinase group > tyrosine protein kinase alk family

Target Components

Component Description Relationship Accession
Leukocyte tyrosine kinase receptor SINGLE PROTEIN P29376

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000062524
Ensembl ENSG00000062524
GO Cellular Component GO:0005622 (intracellular)
GO:0005886 (plasma membrane)
GO:0005887 (integral component of plasma membrane)
GO:0016020 (membrane)
GO:0016021 (integral component of membrane)
GO Molecular Function GO:0000166 (nucleotide binding)
GO:0004672 (protein kinase activity)
GO:0004713 (protein tyrosine kinase activity)
GO:0004714 (transmembrane receptor protein tyrosine kinase activity)
GO:0005515 (protein binding)
GO:0005524 (ATP binding)
GO:0016301 (kinase activity)
GO:0016740 (transferase activity)
GO Biological Process GO:0006468 (protein phosphorylation)
GO:0007165 (signal transduction)
GO:0007169 (transmembrane receptor protein tyrosine kinase signaling pathway)
GO:0008283 (cell proliferation)
GO:0010666 (positive regulation of cardiac muscle cell apoptotic process)
GO:0010976 (positive regulation of neuron projection development)
GO:0014065 (phosphatidylinositol 3-kinase signaling)
GO:0016310 (phosphorylation)
GO:0018108 (peptidyl-tyrosine phosphorylation)
GO:0043066 (negative regulation of apoptotic process)
GO:0071300 (cellular response to retinoic acid)
Wikipedia Leukocyte_receptor_tyrosine_kinase

Target Cross References - Protein

canSAR P29376
Human Protein Atlas ENSG00000062524
IntAct P29376
Guide to Pharmacology 1838
Open Targets ENSG00000062524
PharmGKB PA30483
Pharos P29376 (Tchem)
UniProt A6NNJ8 B4DL89 E9PFX4 P29376

Target Cross References - Domain

InterPro IPR000719 (Prot_kinase_dom.)
IPR001245 (Ser-Thr/Tyr_kinase_cat_dom.)
IPR002011 (Tyr_kinase_rcpt_2_CS.)
IPR008266 (Tyr_kinase_AS.)
IPR011009 (Kinase-like_dom_sf.)
IPR017441 (Protein_kinase_ATP_BS.)
IPR020635 (Tyr_kinase_cat_dom.)
Pfam PF07714 (Pkinase_Tyr)