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Target Report Card

Target Name and Classification

Target ID CHEMBL5626
Target Type SINGLE PROTEIN
Preferred Name SHC-transforming protein 1
Synonyms SH2 domain protein C1 | SHC | SHC-transforming protein 1 | SHC-transforming protein 3 | SHC-transforming protein A | SHC1 | SHCA | Src homology 2 domain-containing-transforming protein C1
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
SHC-transforming protein 1 SINGLE PROTEIN P29353

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000160691
Ensembl ENSG00000160691
GO Cellular Component GO:0005634 (nucleus)
GO:0005737 (cytoplasm)
GO:0005739 (mitochondrion)
GO:0005759 (mitochondrial matrix)
GO:0005829 (cytosol)
GO:0005886 (plasma membrane)
GO:0010008 (endosome membrane)
GO:0070435 (Shc-EGFR complex)
GO Molecular Function GO:0001784 (phosphotyrosine binding)
GO:0005068 (transmembrane receptor protein tyrosine kinase adaptor activity)
GO:0005088 (Ras guanyl-nucleotide exchange factor activity)
GO:0005154 (epidermal growth factor receptor binding)
GO:0005158 (insulin receptor binding)
GO:0005159 (insulin-like growth factor receptor binding)
GO:0005168 (neurotrophin TRKA receptor binding)
GO:0005515 (protein binding)
GO:0005543 (phospholipid binding)
GO:0030971 (receptor tyrosine kinase binding)
GO:0032403 (protein complex binding)
GO:0046875 (ephrin receptor binding)
GO:0051219 (phosphoprotein binding)
GO:0051721 (protein phosphatase 2A binding)
GO Biological Process GO:0000165 (MAPK cascade)
GO:0000187 (activation of MAPK activity)
GO:0001525 (angiogenesis)
GO:0001666 (response to hypoxia)
GO:0007165 (signal transduction)
GO:0007173 (epidermal growth factor receptor signaling pathway)
GO:0007176 (regulation of epidermal growth factor-activated receptor activity)
GO:0007265 (Ras protein signal transduction)
GO:0007507 (heart development)
GO:0007568 (aging)
GO:0008284 (positive regulation of cell proliferation)
GO:0008286 (insulin receptor signaling pathway)
GO:0009636 (response to toxic substance)
GO:0014070 (response to organic cyclic compound)
GO:0016032 (viral process)
GO:0016337 (single organismal cell-cell adhesion)
GO:0030036 (actin cytoskeleton organization)
GO:0030182 (neuron differentiation)
GO:0031100 (organ regeneration)
GO:0031175 (neuron projection development)
GO:0031532 (actin cytoskeleton reorganization)
GO:0032868 (response to insulin)
GO:0032869 (cellular response to insulin stimulus)
GO:0035094 (response to nicotine)
GO:0035556 (intracellular signal transduction)
GO:0036498 (IRE1-mediated unfolded protein response)
GO:0038095 (Fc-epsilon receptor signaling pathway)
GO:0038128 (ERBB2 signaling pathway)
GO:0040008 (regulation of growth)
GO:0042127 (regulation of cell proliferation)
GO:0042542 (response to hydrogen peroxide)
GO:0043547 (positive regulation of GTPase activity)
GO:0045740 (positive regulation of DNA replication)
GO:0045907 (positive regulation of vasoconstriction)
GO:0048661 (positive regulation of smooth muscle cell proliferation)
GO:0050900 (leukocyte migration)
GO:0051384 (response to glucocorticoid)
GO:0071363 (cellular response to growth factor stimulus)
Wikipedia SHC1

Target Cross References - Protein

canSAR P29353
Human Protein Atlas ENSG00000160691
IntAct P29353
Open Targets ENSG00000160691
PharmGKB PA35746
Reactome R-HSA-114604 (GPVI-mediated activation cascade.)
R-HSA-1236382 (Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants.)
R-HSA-1250196 (SHC1 events in ERBB2 signaling.)
R-HSA-1250347 (SHC1 events in ERBB4 signaling.)
R-HSA-167044 (Signalling to RAS.)
R-HSA-180336 (SHC1 events in EGFR signaling.)
R-HSA-210993 (Tie2 Signaling.)
R-HSA-2424491 (DAP12 signaling.)
R-HSA-2428933 (SHC-related events triggered by IGF1R.)
R-HSA-2730905 (Role of LAT2/NTAL/LAB on calcium mobilization.)
R-HSA-2871796 (FCERI mediated MAPK activation.)
R-HSA-2871809 (FCERI mediated Ca+2 mobilization.)
R-HSA-354192 (Integrin alphaIIb beta3 signaling.)
R-HSA-381038 (XBP1(S) activates chaperone genes.)
R-HSA-392451 (G beta:gamma signalling through PI3Kgamma.)
R-HSA-451927 (Interleukin-2 signaling.)
R-HSA-512988 (Interleukin-3, 5 and GM-CSF signaling.)
R-HSA-5637810 (Constitutive Signaling by EGFRvIII.)
R-HSA-5654688 (SHC-mediated cascade:FGFR1.)
R-HSA-5654699 (SHC-mediated cascade:FGFR2.)
R-HSA-5654704 (SHC-mediated cascade:FGFR3.)
R-HSA-5654719 (SHC-mediated cascade:FGFR4.)
R-HSA-5673001 (RAF/MAP kinase cascade.)
R-HSA-74749 (Signal attenuation.)
R-HSA-74751 (Insulin receptor signalling cascade.)
R-HSA-8851805 (MET activates RAS signaling.)
R-HSA-8853659 (RET signaling.)
R-HSA-912526 (Interleukin receptor SHC signaling.)
R-HSA-983695 (Antigen activates B Cell Receptor (BCR) leading to generation of second messengers.)
UniProt B5BU19 D3DV78 O15290 P29353 Q5T180 Q5T183 Q5T184 Q5T185 Q5T186 Q8N4K5 Q96CL1

Target Cross References - Domain

InterPro IPR000980 (SH2.)
IPR006019 (PID_Shc-like.)
IPR006020 (PTB/PI_dom.)
IPR011993 (PH_dom-like.)
IPR029586 (Shc1/ShcA.)
Pfam PF00017 (SH2)
PF00640 (PID)

Target Cross References - Structure

PDBe 1MIL 4JMH 4XWX 5CZI
CREDO 1MIL 4JMH 4XWX 5CZI
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