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Target Report Card

Target Name and Classification

Target ID CHEMBL5618
Target Type SINGLE PROTEIN
Preferred Name Aryl hydrocarbon receptor nuclear translocator
Synonyms ARNT protein | ARNT | Aryl hydrocarbon receptor nuclear translocator | BHLHE2 | Class E basic helix-loop-helix protein 2 | Dioxin receptor, nuclear translocator | HIF-1-beta | HIF1-beta | Hypoxia-inducible factor 1-beta | bHLHe2
Organism Homo sapiens
Species Group No
Protein Target Classification
  • unclassified protein

Target Components

Component Description Relationship Accession
Aryl hydrocarbon receptor nuclear translocator SINGLE PROTEIN P27540

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000143437
Ensembl ENSG00000143437
GO Cellular Component GO:0005634 (nucleus)
GO:0005654 (nucleoplasm)
GO:0005667 (transcription factor complex)
GO:0005737 (cytoplasm)
GO:0090575 (RNA polymerase II transcription factor complex)
GO Molecular Function GO:0000989 (transcription factor activity, transcription factor binding)
GO:0003677 (DNA binding)
GO:0003700 (transcription factor activity, sequence-specific DNA binding)
GO:0003705 (transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding)
GO:0003713 (transcription coactivator activity)
GO:0004874 (aryl hydrocarbon receptor activity)
GO:0005515 (protein binding)
GO:0008134 (transcription factor binding)
GO:0017162 (aryl hydrocarbon receptor binding)
GO:0035326 (enhancer binding)
GO:0043565 (sequence-specific DNA binding)
GO:0046982 (protein heterodimerization activity)
GO:0046983 (protein dimerization activity)
GO Biological Process GO:0001666 (response to hypoxia)
GO:0001892 (embryonic placenta development)
GO:0001938 (positive regulation of endothelial cell proliferation)
GO:0006351 (transcription, DNA-templated)
GO:0006355 (regulation of transcription, DNA-templated)
GO:0010575 (positive regulation of vascular endothelial growth factor production)
GO:0030154 (cell differentiation)
GO:0030522 (intracellular receptor signaling pathway)
GO:0030949 (positive regulation of vascular endothelial growth factor receptor signaling pathway)
GO:0033235 (positive regulation of protein sumoylation)
GO:0042789 (mRNA transcription from RNA polymerase II promoter)
GO:0043619 (regulation of transcription from RNA polymerase II promoter in response to oxidative stress)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045821 (positive regulation of glycolytic process)
GO:0045893 (positive regulation of transcription, DNA-templated)
GO:0045944 (positive regulation of transcription from RNA polymerase II promoter)
GO:0046886 (positive regulation of hormone biosynthetic process)
GO:0061418 (regulation of transcription from RNA polymerase II promoter in response to hypoxia)
Wikipedia Aryl_hydrocarbon_receptor_nuclear_translocator

Target Cross References - Protein

canSAR P27540
Human Protein Atlas ENSG00000143437
IntAct P27540
Open Targets ENSG00000143437
PharmGKB PA24994
Reactome R-HSA-1234158 (Regulation of gene expression by Hypoxia-inducible Factor.)
R-HSA-1989781 (PPARA activates gene expression.)
R-HSA-211945 (Phase 1 - Functionalization of compounds.)
R-HSA-211976 (Endogenous sterols.)
R-HSA-211981 (Xenobiotics.)
R-HSA-8937144 (Aryl hydrocarbon receptor signalling.)
UniProt B2R9H1 C4AMA1 F8WAP6 P27540 Q59ED4 Q5QP39 Q8NDC7

Target Cross References - Domain

InterPro IPR000014 (PAS.)
IPR001067 (Nuc_translocat.)
IPR001610 (PAC.)
IPR011598 (bHLH_dom.)
IPR013767 (PAS_fold.)
Pfam PF00010 (HLH)
PF00989 (PAS)

Target Cross References - Structure

PDBe 2B02 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP
CREDO 2B02 3F1N 3F1O 3F1P 3H7W 3H82 4EQ1 4GHI 4GS9 4H6J 4LPZ 4PKY 4XT2 5TBM 5UFP
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