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ChEMBL

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ChEMBL Statistics
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Target Report Card

Target Name and Classification

Target ID CHEMBL5616
Target Type SINGLE PROTEIN
Preferred Name Activin receptor type-2A
Synonyms ACTR-IIA | ACTRIIA | ACVR2 | ACVR2A | Activin receptor type IIA | Activin receptor type-2A
Organism Homo sapiens
Species Group No
Protein Target Classification
  • enzyme > kinase > protein kinase > tkl protein kinase group > tkl protein kinase stkr family > tkl protein kinase stkr type 2 subfamily

Target Components

Component Description Relationship Accession
Activin receptor type-2A SINGLE PROTEIN P27037

Target Associated Bioactivities

Target Associated Assays

Target Ligand Efficiencies

Target Associated Compound Properties

Target Cross References - Gene

Array Express ENSG00000121989
Ensembl ENSG00000121989
GO Cellular Component GO:0005737 (cytoplasm)
GO:0005887 (integral to plasma membrane)
GO:0034673 (inhibin-betaglycan-ActRII complex)
GO Molecular Function GO:0004702 (receptor signaling protein serine/threonine kinase activity)
GO:0005024 (transforming growth factor beta receptor activity)
GO:0005524 (ATP binding)
GO:0015026 (coreceptor activity)
GO:0046872 (metal ion binding)
GO:0048186 (inhibin beta-A binding)
GO Biological Process GO:0001934 (positive regulation of protein phosphorylation)
GO:0006468 (protein phosphorylation)
GO:0030501 (positive regulation of bone mineralization)
GO:0030509 (BMP signaling pathway)
GO:0032924 (activin receptor signaling pathway)
GO:0032927 (positive regulation of activin receptor signaling pathway)
GO:0045648 (positive regulation of erythrocyte differentiation)
GO:0045669 (positive regulation of osteoblast differentiation)
Wikipedia ACVR2A

Target Cross References - Protein

canSAR P27037
Human Protein Atlas ENSG00000121989
IntAct P27037
Guide to Pharmacology 1791 (activin A receptor, type IIA)
PharmGKB PA24494
Reactome REACT_12034 (Signaling by BMP.)
UniProt B2RAB8 D3DP85 P27037 Q53TH4 Q6NWV2 Q92474

Target Cross References - Domain

InterPro IPR000333 (Activin_II/TGFBeta-II_recpt.)
IPR000472 (Activin_rcpt.)
IPR000719 (Prot_kinase_cat_dom.)
IPR008271 (Ser/Thr_prot_kinase_AS.)
IPR011009 (Kinase-like_dom.)
IPR015768 (Activin_II_recpt.)
IPR017442 (Se/Thr_prot_kinase-like_dom.)
Pfam PF00069 (Pkinase)
PF01064 (Activin_recp)

Target Cross References - Structure

PDBe 3Q4T
CREDO 3Q4T
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